A Simple Guide to Cholesterol on Low Carb – Part I

If you’re on a Low Carb High Fat diet (LCHF), there are a few things you should know about cholesterol and how it is related to this lifestyle. In this guide I plan to cover the topic in very simple terms. It is by no means complete and is intentionally simplified to make it easier to read and understand for the layperson.

Our Energy on a High Fat Diet

Before talking about cholesterol, we have to talk about the energy you get from fat when on LCHF. Of course the main reason for food is to supply your body with energy. But how does that energy get to everywhere it needs to go in your body?

Like every other living thing, your body is made up of cells. Your heart is made of cells. Your brain is made of cells. So are your fingers, knees and toes. Almost all these cells need energy. And the vast majority of these cells ultimately get their energy from the blood circulating around your body.

Bloodstream

The most commonly talked about source of energy is carbohydrates (carbs). Your body turns carbs into glucose to put in the bloodstream. From there, the glucose can circulate throughout the body, allowing hungry cells to grab some for themselves, and this is done with the help of insulin.

Glucose

The other major energy source for your cells is fat, and by that I mean fatty acids. And like glucose, your cells also get their fatty acids from the bloodstream. Only there’s an important catch: glucose can swim in the bloodstream easily, but fatty acids cannot.

Fatty acids and the bloodstream are like oil and water, they don’t mix well. To fix this, your body cleverly does two things:

  1. It packages three fatty acids into a combo pack molecule called a “triglyceride”.
  2. And it makes a kind of boat for these triglycerides to travel in called a “lipoprotein”.

In fact, the kind of lipoprotein that delivers all these fatty acids is known as a very low density lipoprotein — or VLDL. After it delivers its energy, it remodels to a low density lipoprotein — but you probably know it already by its abbreviation, LDL.

Trigs vs Glucose

Common Confusion with LDL

Odds are you have most likely heard of LDL being used to describe cholesterol on a blood test. “Your LDL is high…” for example. So what gives?

Here’s the thing about cholesterol, like its triglyceride cousin, it also doesn’t swim well in the bloodstream. In the medical world, these molecules are commonly referred to as lipids. And lipids are actually repelled by water, so they are commonly called hydrophobic (hydro = water, phobic = repel). So when someone tells you they love to go to the beach but hate the water, mention they must be hydrophobic like cholesterol!

Yet what if the body has reason to have cholesterol available in the bloodstream as well? (We’ll get into that more in Part II) And while we’re on the subject, there are a few other things the body wants available to cells that are also hydrophobic, such as fat soluble vitamins (like Vitamin E).

So should it make a separate lipoprotein container for each of these molecules? No! It effectively packages all of them into the same boat: the lipoprotein.

Lipoprotein

That’s the genius of the human body. It has a kind of FedEx for all the hydrophobic elements needed by the cells. And most of whatever isn’t used gets recycled by the liver for many other possibilities, such as hormone or bile salt production.

Common Confusion with Triglycerides

The odds are likewise that you’ve heard “triglycerides go down on a low carb diet”. Indeed, blood tests for those going LCHF are almost universally lower in triglycerides. But a measurement of anything in the bloodstream is counting what is traveling around in that moment and not yet in use.

For example, Type 2 Diabetes has a common symptom of having very high glucose in the blood. This is because these diabetics are insulin resistant and have trouble getting the glucose out of the blood and into their cells. They may eat the same quantity of food as someone who isn’t diabetic, but glucose in the blood will spike higher and last longer by comparison.

If you have reduced your carbs and now get your energy mainly from fat, without question your cells are absorbing more of it from the bloodstream now. So even if you’ve increased the total amount of triglycerides going into the blood due to the diet, it is still brought down by the amount getting taken back out and used by the cells.

Common Confusion With Ketones

Another common assumption with LCHF is that you “get the majority of your energy from ketones” since you are in a state of ketosis. It’s certainly true your body makes many more ketone bodies from breaking down fatty acids, which will likewise feed your cells. This is especially important for proper brain function as ketones have special access that lipoproteins do not.

Yet while ketones are both produced and used much more on LCHF, they are still a secondary source of energy. The primary source of energy is still fatty acids brought to cells in LDL particles.

Ketones

More Cholesterol is Trafficked on a Low Carb High Fat Diet

Now that you understand your body has need to move around more triglycerides to fuel your cells while getting the majority of your energy from fat, you may have already connected the dots.

  1. Your cells need energy
  2. On a high fat diet, their primary source of energy is triglycerides
  3. To get the triglycerides to your cells, your body sends them in very low density lipoproteins (VLDLs), which eventually remodel to low density lipoproteins (LDLs).
  4. All very low density lipoproteins (VLDLs) are made containing both triglycerides and cholesterol (but mostly triglycerides)

What are the Risks?

If you read the above and are struck with fear, I don’t blame you. It has been well drilled into our heads that more cholesterol in the blood = higher risk of cardiovascular disease and stroke.

But if you’re early in your research on this topic, let me help you skip ahead with one very crucial point (which I alluded to above). Making something available is not the same as using it.

Here’s a simple analogy – life rafts in the water and being used are typically a sign of trouble. Yet all ships sail with them on board. This is a good idea in case of an emergency, of course. But if you were only counting life rafts whether in use or not, then you’d assume a lot of ships entering view was by itself a sign of trouble.

Cholesterol is like the life rafts on the LDL ships. Even if it travels with your triglycerides, it is a much smaller passenger (in quantity) and mostly recycled back at the liver. You don’t actually care how much cholesterol is in your blood — you care how much cholesterol leaves the bloodstream and causes a build up of plaque in your arteries (atherosclerosis). And this is at the core of the inflammation debate with cholesterol. Is it a life raft for damage to the blood vessels? Or is the sheer presence of it risk alone? (You can probably guess where I fall on this one.)

In Part II we cover part of the journey of cholesterol in more detail through a very visual comic form. (Part III is coming soon…)

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Samantha Baker
Samantha Baker
6 years ago

Great post Dave, love it! Makes it all so simple to understand. Bravo!

bill
6 years ago

Fun!

Joe
Joe
6 years ago

Thank you for the time you put into this excellent and simple summary. Looking forward to the series so I can share it with my less geeky friends in the hope that their eyes can be opened. Will likely also share with my doc who I have brought on board with LC but not HF. Gave him Big Fat Surprise for Christmas and hope it will have the same effect as Why We Get Fat!

Dave Winebrenner
Dave Winebrenner
6 years ago

I can see the particle count people circling the wagons now Dave:)

I am with you on this!

Awesome first part.

Diana
Diana
6 years ago

Terrific explanation. looking forward to part 2

Wim Tilburgs
6 years ago

Great explanation. Will share it. Looking forward to part 2

Maarten
Maarten
3 years ago
Reply to  Wim Tilburgs

Hé Wim misschien iets om in NL te vertalen?

Charles Grashow
Charles Grashow
6 years ago

Dave

You said – “In Part II, I’ll discuss my own research and data, and why it has alleviated my concerns about having high cholesterol while on a low carb diet in greater depth.”

SO – if high cholesterol on a LC diet is not really a concern why do all of these experiments with regard to cholesterol?

Angela
Angela
6 years ago

Great explanation! And way to leave me hanging. 🙂 Looking forward to part 2

Doug
Doug
6 years ago

Perhaps part II will answer my question, but you say: All low density lipoproteins are made containing both triglycerides and cholesterol (but mostly triglycerides). (Emphasis mine.)

What are your sources for that? The trig/chol ratio in an LDL particle seems to be something that is highly variable, and IMO, clearly not true for folks with high LDL-C and low trigs – your point about the traffic vs content notwithstanding, at a given point in time, those people’s LDL are carrying mostly cholesterol. Also, mostly trigs in your LDL makes for small dense LDL, which is generally accepted to be a bad thing.

One pertinent tidbit you glossed over is that on a high carb diet, once glycogen stores are high, the liver will convert calories not immediately needed into trigs, which of course, is why folks on high carb diets have high trigs.

Deborah Burdette
Deborah Burdette
6 years ago

Thank you….I’ve always refused the medication for cholesterol and triglycerides……

Chad Nordstrom
Chad Nordstrom
6 years ago

Great job!! Enjoying your efforts and posts. Thanks for sharing all this.

Karen
Karen
6 years ago

What about HDLs I am interested in how HFLC increases HDL Levels, my skin and joints has never been better since being on this diet

Rob
Rob
6 years ago

Great post Dave! I like the different way of looking at it. It all makes complete sense. I’ve had 10 NMR’s myself since starting LCHF in 2011, and my numbers have been high. I would be curious what Dr. Thomas Dayspring had to say, since he says”particle number, end of discussion”. I’m with you though Dave!

Chris Jones
Chris Jones
6 years ago

Hi Dave, this is all very new to me as I’ve started a LCHF diet last week but just got back the results for my cholesterol tests and they are high. That prompted the question “how am I supposed to reduce fat intake if I’m on a LCHF diet?”. Based on the misinformation surrounding the whole “fat makes you fat” nonsense, I don’t fully trust what the doctor is telling me regarding reducing fat to improve cholesterol numbers.

So after reading this post a couple times, I came to the following summary. Please tell me if I’m misunderstanding:

– The body packages three fatty acids into triglycerides

– LDL carries both these triglycerides AND cholesterol through the blood stream

– This allows the triglycerides to be absorbed and used as energy (“burning fat”)

– Also allows the cholesterol to move through the bloodstream rather than to build up as plaque

Now if I’m right on these points, then I also have the following questions:

– Why is a high LDL count bad? It sounds like more LDLs would be better as that means more cholesterol can be carried through the bloodstream rather than building up.

– Where does the cholesterol go if its not building up as plaque?

– How does a LCHF diet affect this process, besides just having more fatty acids and therefore more triglycerides, and therefore more LDL(?)

And to follow up on the last point, the impression I’m getting is that for a diabetic (or close to it) with high cholesterol would be better to just “ignore” the high cholesterol and LDL counts because the fat being burned from the LCHF diet is “worth it” overall, and that eventually it all balances out naturally over time because the body as a whole becomes healthier.

I’m not the sharpest bulb in the box as you may have noticed, but I’m trying my best to at least understand at a very fundamental level what is going on when you combine LCHF with a high cholesterol number.

Nicole Recine
Nicole Recine
6 years ago

I love this! This helped me understand why Peter Defty told me cardio may help lower my trigs. I just need to use them. On to part 2 🙂

Drifter
Drifter
6 years ago

Dave,
Thanks for taking on this topic…Several things, in case you haven’t seen it, here is Dr. Rocky Patel’s post where he describes how his particle count was “high” when he went LCHF, however his arterial plaque actually reduced during that same period. That to me is the holy grail so evidence like that from clinicians seems particularly important. He also has a good discussion of the inflammation markers he uses and some good discussion in the comments section. Unfortunately he doesn’t seem to be blogging or podcasting anymore, but here is the post:

http://azsunfm.blogspot.com.br/2012/09/font-definitions-font-face-font-family.html

Also, I haven’t seen you cover oxidized cholesterol, but maybe I missed it. I would strongly recommend Chris Masterjohn’s writing on this topic if you haven’t seen it. I am also a hyper-responder so I have been following this topic for a number of years. While it seems fairly clear that many people can have what mainstream “medicine” would consider elevated cholesterol and still be perfectly healthy, there are also some other issues which can also creep in which are likely worth addressing. Specifically, Dr. Gundry has said that in his experience he often sees people with a high level of oxidized LDL which resolves if they switch to A2 casein instead of A1 casein and reduce cheese consumption. It seems that while LDL is far from the most important issue, it is still worth considering if related factors like problem foods are creating an unnecessary elevation.

Ray Klepper
Ray Klepper
6 years ago

Dave,
Thank you so much for your continued pursuit of this topic. I am a physical therapist and have been relentless with my self education regarding nutrition over the past 2 years. I am scheduled to speak with a cardiothoracic surgeon who is very into nutrition and primary prevention as well. His interest is how to best lower LDL without a statin. I’m not sure how he will respond when I bring up the idea that LDLc is a terrible biomarker per Dr.Dayspring and per other articles, data and experience. What I would like is to use your examples to tell the story and also to pick your brain a bit more regarding specific nuances to make sure I have my bases covered. If you are able to could we communicate through email? I will leave my email below and hope to hear from you. Thanks again.

Rob
Rob
6 years ago
Reply to  Ray Klepper

Hi Ray and Dave–I’m a speech therapist at a major hospital in DC and am developing nutritional advice for stroke patients along with help from clinical dietitians. Unfortunately they are very usda guidelines focused and tend to recommend way more grains and carbs than I do and they definitely steer patients away from saturated fats. Any luck developing good advice for lowering patients risk of cardiovascular disease? Feel free to email me or connect me to Ray. Thanks.

Pat
Pat
6 years ago

I see your previous comments re: Dr Attia so no need to respond!!

Andrea Mikler
Andrea Mikler
6 years ago

Dave,

just found your site today and can’t stop reading. I love your analytical engineering aproach to it. When are you going to write about HDL?
I am very interested to know the mechanism of my HDL increasing on ketogenic diet to the point that is much higher than my LDL. I have been on low carb for about 4 years with the last year being mostly keto. My Total chol in 2013 was 200, HDL was 94, LDL 100 and Trigs 0.38. My last test in Sept. 2016 Total chol. 238, HDL 125, LDL 103, Trigs 0.5. What does it mean when HDL is higher than LDL and is that ever a concern? I do not see this ratio very often.

Thank you for all your work

Andrea Mikler
Andrea Mikler
6 years ago
Reply to  Andrea Mikler

Oh just noticed I converted cholesterol numbers from mm/l to mg/dl but did not convert triglycerides. They went from 34 to 44.

Dave Braatz
6 years ago

Might need another category: My cholesterol and triglycerides have always been high, but I remained skeptical of taking statins. From 2001 to 2017 (N=22), my TC averaged 260; TG avg 356; HDL avg 37; LDL avg 169; glucose 94 (all after 12-hr fast, and on HCLF diet).

In 2010, my blood after a 4-day water-only fast showed TC=312; TG=271; HDL=34; LDL=224; and glucose=62. I assumed my TG dropped because my glucose fell, but I was surprised at the jump in my TC.

I went keto in 2017, and my June bloodwork (non-fasting; LCHF) showed a huge spike in TC to 397; a spike in TG to 740; a drop in HDL to 29; LDL not calculated; and glucose at 92. The rise in TC fits the hyper-responder profile, but WHY would my triglycerides skyrocket (especially with a modest non-fasting glucose at 92), and why would my HDL drop?

I did the June blood test as non-fasting because of the logic in the Life Extension article “Should you fast before a blood test?” in their May 2017 issue. Good reasoning, and I’d appreciate your opinion. http://www.lifeextension.com/Magazine/2017/5

Leigh Brown
Leigh Brown
5 years ago
Reply to  Dave

Hey Dave, possibly similar to the above. 5 months into a carnivore diet (fatty steak, bacon, eggs, water). Triglycerides are moving a bit, but still stubbornly high. Have a good doctor on the journey so no panic there. TC 9.1 (steady over 2 months and 3 tests) /HDL 1.3 (up from 1)/ LDL 6.7 (down from 6.9)/ TG 2.3 (down from 2.9). 6’3″ and weighed 102kg’s, now down to 86kg’s. I understand the protocol of more TC and TG being dumped into the bloodstream and that it will (should) settle down as my weight settles out. Doctor doesn’t believe I have any issues with insulin or hypercholersterolemia (TC was 5.1 about 3 years ago). Using your calculator I fall into high risk on both measures. For what it’s worth….I feel fantastic at 45. Can i send my blood work through to you?

Leigh Brown
Leigh Brown
5 years ago
Reply to  Dave

Dave, awesome that you replied so quickly mate, thank you very much. I agree on the TG dropping which is why
I found a new doctor familiar with low carb and we’ve been working closely to track changes etc (4 blood tests this year). Briefly….did Jan and Feb as keto with all of the associated fat bombs and heavy cream etc (no keto supplement stuff, all real food). Carbs are definitely zero. Have been carnivore since March (bacon, eggs, steak, bone broth, water). The one that jumps out now is your point about coffee….bugger! I have about 5-6 espresso each day. Next blood test is in 6 weeks so will have my last coffee today and see what happens. If it’s not coffee then we are also focusing on insulin and liver….don’t know what else could be the issue.

David
6 years ago

This is a subject close to my heart cheers.
Thanks

Scout Dawson
6 years ago

Dr. Michael Eades linked to your website, so I thought I would check it out. This ‘beginner’s guide’ is amazing and really informative. The cholesterol thing is something I have always been quite confused about (and I did wonder why long-term keto’s had “high” blood pressure after many years).

This has cleared up any worries I had. Time for a steak? 😉

Roger
Roger
6 years ago

Dave,

Your work is awesome! I use your data to disrupt conventional medicine every chance I get. That said, what is your generic advice for FH patients?

Thanks,

Roger

Leslie
Leslie
6 years ago

This article is very good in helping me understanding cholesterol. I started a LCHF way of eating about 5 weeks ago. I lost some weight but didn’t have much to lose. I went to my yearly appointment and they checked my labs. My TC was 290 and my LDL was 210. I am 37 years old, 5’4″ and weigh 117. I don’t know if that information matters. From my understanding, these numbers don’t mean anything and I would have to have my particles checked to see if there is a real issue. thanks in advance for any information.

Mansoor
Mansoor
6 years ago

Hi Dave thanks for the invaluable insight you gave me about cholesterol. After 4 months of keto I had my blood work done I realized my cholesterol was high.My weight is 70 kg and I’m 178 cm high.I’m moderately active .

Total: 238
LDL : 160
VLDL:12
HDL : 66
Triglyceride: 62

I have heard if LDL cholesterol is over 130 it’s not healthy and the small dence particles are high. I don’t know how they came up with this number.In my country NMR test doesn’t exist.I really love this diet but there are alot of confusion. How can i get more information about my condition? Thanks you so much.

Pratik Jhaveri
Pratik Jhaveri
5 years ago

Dave
Been on a LCHF diet for the last 2.5months (was in keto for a bit). Lost ~20lbs during that time. Went in for my blood test last week and was surprised to find that my cholesterol went up. Good news is that A1C dropped.

A1C – went from 6.3 to 5.7
Total Chol – from 257 to 292
LDL – from 181 to 212
TG – from 194 to 215
HDL – remained same at 37

I read through your simple guide to cholesterol and was trying to understand the reasons for the possible increase. In addition, what other tests should I do to get a more accurate picture of the risks?

Lisa Mayo
Lisa Mayo
5 years ago

Hi Dave
Thanks for your work.
Trying to understand the numbers and conversions and just looking for some clarity of direction. If you have the time please can you check my recent blood work.
I am a 54 yo female , train 3-5 times weekly weights / cardio 62 kg and 154cm.
total cholesterol 8.3
trigs .0.9
hdl 2.1
ldl 5.8
hbaic5.2
fasting glucose 4.2
CRP 0.5
Thinking low trigs , CRP and fasting glucose good and HBAiC in range probably a good predictor. however high LDD and total cholesterol still a red flag but with low trigs my be a indicatory of minimal risk of small dense LDL particles ? Think a cac scan and lipid subtraction analysis will give greater clarity?
Appreciate your thoughts
Thanks again
Lisa M

Lisa mayo
Lisa mayo
5 years ago

Thanks Dave yes thought I might fit into the hyper responders group . Thanks for your teply . Also great presentation at the Gold Coast gave more clarity to my numbers and my understanding

Stefan
Stefan
5 years ago

Great ..is there a write up where you explain HDL (Good), LDL (Bad) Cholesterol and Triglycerides. New to this an my doc always wants to put me on pills to lower my cholesterol ..like to get more informed before I swallow a pill. ( sorry about my english I am from europe) . thx
Stefan

Craig
Admin
Craig(@tigris)
5 years ago
Reply to  Stefan

Start with the Simple Guide.

Lou Malinow
5 years ago

Very well done. I am an internist, a lipidologist, and a hypertension specialist and I preach ketosis for many patients. I would make one constructive comment……a “typical” LDL particle is 4 parts cholesterol to 1 part triglyceride, so most of the baggage on the ships isn’t triglyceride (unless you’re dealing with an insulin resistant patient with high VLDL). VLDL (recipe: combine a bunch of triglyceride with a little cholesterol and wrap it with a lipoprotein called ApoB which you might refer to as the hull of the boat) has a triglyceride to cholesterol ratio of 5:1……..and that may be what you’re referring to.

Evie
Evie
5 years ago

Hi Dave…it’s a good summary when I am looking for an article about TG. After 3 months on Keto when I did blood test my TG was increasing very significant, which is strange. Before Keto, I have done also a lot of diet such as low carb high protein, food combining, etc and my blood test always good. Ratio of TG and HDL is less than 2. But SGOT and SGPT always high before and after 3 mos on keto, those are decrease significantly but TG was increase. Logically it’s not like that, TG should be low rite…that’s I am trying to get the information why…I hope I can find the answer in your research…

Ray Klepper
Ray Klepper
5 years ago

Hey Dave, had a question about my history with lipid testing. Can you please email me so we can discuss? TIA!

Danny
Danny
5 years ago

This is awesome for dumb guys like myself. Thanks!

mike
mike
5 years ago

Great post and blog! I actually noticed similar results to your experiment! I was so worried about my high LDL but it dropped so much after switching to the SAD diet. I detailed my experience here: https://www.reddit.com/r/keto/comments/81on0f/dont_be_worried_about_your_high_ldlc_on_keto_my/

Thanks again 🙂

jeff daniels
jeff daniels
5 years ago

you’re sharp. try taking a crack at this:In the 3 months between tests-i started keto, stopped statins . AND took weekly iv plaquex(phosphodytlcholine sessions. my
ldl-p doubled to 2034, tg from 98 to 83, insulin from 10 to 3, hdl from 40 to 50-ldl-73 to 143 crp from 1.9 to 4. I am going back on statin to lower crp but am i wrong-during fasts chol. rises in blood-Dr. Furhman says that’s because it’s coming out of the plaques. I think the plaquex sucked stuff out of plaque i am dying to get an ultra sound of caratids hopefully my narrowed ones have expanded due to the plaquex. Am I wrong or is it the low carbs thanks jeff daniels
ldl

Vijay
Vijay
5 years ago

Thanks for this Dave, A simple explanation that I can also point my GP to 🙂

Patty
5 years ago

Hi Dave, I have a question for you, I have a friend who is not overweight (great physical shape, exercises daily but follows SAD) but he suffers from high cholesterol due to it being hereditary, he is taking statins currently, I told him that a low carb/ketogenic diet would help him get off from them and he said that if I showed him a peer reviewed study, he would consider it. Do you have one that can help me? Thanks in advance. (I read about you from Tyler @Ketogains, I’m a bootcamper)

Siobhan Huggins
Admin
Siobhan Huggins(@siobhanh)
5 years ago
Reply to  Patty

Hi Patty, I’m helping Dave handle comments while he gets caught up after his return from his hiatus 🙂

As for your friend, if his high cholesterol is truly genetic (As in Familial Hypercholesterolemia) then diet actually shouldn’t affect it to the point of “normalizing” it. The high cholesterol in that case would be due to some differences in how his system works as opposed to metabolic health issues or fat metabolism that we typically see.
However, there may be some things for him to consider.

Number one is – beyond just LDL or total cholesterol – what does his over all lipid panel look like? It can be a great window into metabolic health if you take all the information together. For example, how high are his triglycerides? What is his HDL level? What about Remnant Cholesterol? Dietary changes would likely be able to influence these factors by influencing over all health.
There’s some recent info from Virta on this in which patients on a ketogenic diet had pretty much all risk markers lowered into a lower risk range… granted they were diabetic, but may be applicable to the wider population with poor markers.

https://blog.virtahealth.com/blood-lipid-changes-with-ketogenic-diet/

The other thing to note is that there is a study for those with FH in which the major difference between those who had had a Myocardial Infarction and those who hadn’t wasn’t LDL level (they were about the same) but rather the level of insulin, and insulin resistance between the two groups (high IR/insulin = MI) as well as some other markers like high triglycerides in the MI group.

https://www.ncbi.nlm.nih.gov/pubmed/11253736

Hopefully that helps!

Sam Kassouf
Sam Kassouf
5 years ago

Dave,
I’m so confused about the Feldman protocol are you saying that if I did a ten day fast before my blood draw that my ldl number would theoretically be higher?I am leaner than I have been in 45 years but my ldl was 278,hdl70,trigs 65 370 total I am willing to pay to get retested…maybe You can use me in your study….How worrisome are my numbers ?

Sam Kassouf
Sam Kassouf
5 years ago
Reply to  Dave

I am 67 years old 6’ 3” and weigh 204 I do a minimum of 30 minutes interval cardio daily and resistance training at about 80% max four times per week.I have lost 64 pounds this last year.I did low carb omad first 10 months keto included these last two months.my scale says 17.4% body fat.Im not sure how accurate it is but the fat% number keeps going down…I have had knee surgery and a broken wrist all in the last 6 months.Inflamation is definitely way down.I feel 20 years younger.I only know for sure I am not going to take the statin drugs my doctor wants me to do.I have seen you in Breckinridge and several other videos…I will research everything you suggested.Im intent on trying my best to educate myself…Thank you so much for your quick response…

Bengt
Bengt
5 years ago

Hi Dave
I don’t understand the process of how plague is building up in the arteries. Could you please explain this process. This is really an important question for me. Thank you for all your explanations about the cholesterol. But I can’t find how the process of plague is building up…..

Siobhan Huggins
Admin
Siobhan Huggins(@siobhanh)
5 years ago
Reply to  Bengt

I actually wrote an article on this exact topic for the site, you can find it here.
Maybe it will help 🙂

Bengt
Bengt
5 years ago

Hi Siobhan.
Thanks for a very interesting article. Great job 🙂 But I don’t really understand how to avoid plague is building up. I am eating LCHF because my cholesterol readings is better. Is it possible for you to in an easy way tell me how to avoid plague? Is LCHF a method for avoiding plague? Is it the carbs who a responsible for the plague building up or what.. 🙂 ?

Siobhan Huggins
Admin
Siobhan Huggins(@siobhanh)
5 years ago
Reply to  Bengt

Hi Bengt,
While I can’t say for sure what exactly causes it (or how to prevent it) especially as I’m not a doctor, I can say that my leading theory is that damage to the arteries seems to be the starting point and aggravating point for progressive plaque accumulation. This can come in different forms – exposure to pollutants, poor diet (possibly highly refined carbohydrates, and seed oil consumption), lack of sleep or poor sleep quality, and chronic stress (all of these things also cause increased risk of heart troubles).
All of those things also appear to increase insulin resistance, and insulin resistance is very much related with cardiovascular disease risk from what I’ve seen so far.

So a few things: since we don’t know for sure, if you’re worried about it it may be best to do what you think is right (like LCHF, proper sleep, etc), and then just make sure to check in and make sure everything looks okay. How’s your HDL, triglycerides, fasting insulin, hs-CRP, etc. Possibly getting CIMTs at a frequency you’re comfortable with to check for arterial thickening, and even a measure of the actual disease a calcium score (CAC) to check progression every 3-5 years or so.

Sorry I can’t give you a straight answer, but I don’t think anyone knows for sure – all we can do is look for the signs and do our best. Personally for me that’s a LCHF diet, with no seed oils, no refined carbohydrates, proper sleep, etc.

Bengt
Bengt
5 years ago

Thanks for the article… Is it possible for you to tell me in an easy way what I can do to avoid plague building up? Is LCHF a way to go? Is it the carbs who causes plaque?

Cedric
Cedric
5 years ago

Your article is well put together. Even a mainstream doctor or nutritionist can follow along (I jest).

Diane Z
Diane Z
5 years ago

So easy to understand, thanks, onto part 2

LIndsey Kabat
LIndsey Kabat
5 years ago

As you mentioned in an earlier comment, one would think that a higher level of LDL would increase the amount of plaque in arteries, but there was no linear data to support this. Am I understanding that correctly? It seems so counter intuitive.
Can you provide me with the research you used to arrive at this conclusion.
Is there any research showing a correlation with atherosclerosis and inflammation?

Starting grad school for nutrition and I find this concept extremely compelling.

Good luck with your future research. I’m looking forward to seeing what you uncover.

Thank you, Dave

CSue
CSue
5 years ago

Love this research. My question is, other than doing the experiments to convince ourselves that you are right (which I already believe), is there any value in doing NMR testing? I haven’t done it in a while and have purchased a test, but not sure what I should do leading up to the test. Just eat like normally, but without any fasting? To get an idea where I am most of the time with my typical diet?

Siobhan Huggins
Admin
Siobhan Huggins(@siobhanh)
5 years ago
Reply to  CSue

Sure – if you just want to use it as a check in for how your current diet is doing you, just go ahead and eat as much and when you normally do, then water fast for 12-14 hours (no coffee, no caffeine, just water). That should give you a pretty good idea. If I had to get basic of basics it would be a lipid panel, NMR, insulin, and hs-CRP just to check in with where I’m at.

Sharon Schellie
Sharon Schellie
5 years ago

Hey Dave, I have found your research informative and quite frankly a bit reassuring. I suffered a widowmaker when I was 47, that has been two years ago. I had 99%, 60%, and 55% blockage in my main arteries of the heart, which now I have 3 stents in place. I recently went off my statins, because of the results it had on my memory, talk about brain fog. I have adapted a low carb lifestyle, but still tend to freak out in regards to my LDL.

Bob
Bob
5 years ago

Dave, first your discussion on ketones in part 1 is WAY to brief to be well understood. For example, where are the ketones made? Do they ride in the VLDL boat? Also, you make this statement: “The primary source of energy is still fatty acids brought to cells in LDL particles.” Is VLDL considered a ‘particle’??? Define a particle please.

Jesus
Jesus
10 months ago
Reply to  Bob

Hi Bob, I believe that you bring excellent questions 🙂 . This said, I enjoyed a lot the above explanations…

Isha Lall
Isha Lall
5 years ago

Wow Dave, this is Incredible. I recently got my whole body analysis and blood test done, where my HDLs were fantastic, triglycerides were low and LDLs fairly raised. I wasn’t as worried as my mom as I being an ex biotechnologist and a software engineer who is now a full time yoga teacher believe in the importance of good fat for the body and brain. After the doctor saw my reports the first thing he said was we need to put you on STATINS. I couldn’t stop myself laughing. Being from india, doctors here are equally vested in giving statins just like the US. Then this morning I wanted to research more on this topic and i stumbled upon a youtube link where Dr. Eric Berg asks you more on cholestrol and hence I got to know about the ‘cholesterolcode.com’ Your work is brilliant, I am still reading it and would love to know more and more on this tooic.

Thanks
Isha Lall

Fazil
Fazil
5 years ago

should i be worried?
..3 months on Standard American ::: 12 hours water fasted…
Total Cholesterol: 235 mg/dL 6.08 mmol/L
LDL Cholesterol: 152 mg/dL 3.92 mmol/L
HDL Cholesterol: 48 mg/dL 1.23 mmol/L
Triglycerides: 179 mg/dL 2.02 mmol/L

–CHOLESTEROL REMNANTS–
Remnant Cholesterol: 35 mg/dL 0.91 mmol/L >>> Medium-High Risk Quintile
Remnant Chol to HDL: 0.73 >>> Medium-High Risk Quintile
Go to https://tinyurl.com/y84u92wm for more on Cholesterol Remnants

–ATHEROGENIC INDEX OF PLASMA (AIP)–
AIP: 0.215 >>> Highest Risk Third
Go to https://tinyurl.com/ycccmmnx for more on Atherogenic Index of Plasma

–CONVENTIONAL MARKERS AND RATIOS–
Friedewald LDL-C: 151 | Iranian LDL-C: 210
Total/HDL Ratio: 4.9
TG/HDL Ratio in mg/dL: 3.73 | in mmol/L: 1.64

Thanks for your feedback

Siobhan Huggins
Admin
Siobhan Huggins(@siobhanh)
5 years ago
Reply to  Fazil

Hi Fazil,
Just to confirm, you were 12-14 hours water fasted for this test?
If so, the high triglycerides are definitely something I would want to address if I were in your shoes. This can usually be done with diet intervention alone, from what I’ve seen. Some things I’ve seen in people that can result in higher triglycerides on a standard american diet include a diet heavy in refined carbohydrates (think bread, pasta, etc). It may also be helpful to get a better look at the context of your results by getting a fasting insulin test, and hs-CRP (inflammation marker).

Fazil
Fazil
5 years ago

How does one know how much cholesterol leaves the bloodstream and causes a build up of plaque in your arteries (atherosclerosis) ? in reference to my high TG

since this is at the core of the inflammation debate with cholesterol

ryan
ryan
4 years ago

Thanks for all the info Dave! I have gotten some vexing blood work done. My doc seems fairly progressive, but I don’t think he is well versed on how to interpret these newer findings. My overall cholesterol has always been borderline high-high. Since being on LCHF my cholesterol total has gone up a bit as expected, but HDL has gone up too and my TG is down to 108 (from 290). However, we did the Quest Cardio IQ test, and some results have me concerned. Namely the Apo B number and the Medium, and small LDL particle numbers. LDL Small, >219 is considered high and mine is 612! LDL Medium, High >301 mine is 615! LDL Pattern B is what it says… APO B High is > or = 120 and mine is 151!. LP(a) Optimal is <75 and mine is 29…. wonder if I am a hyper responder? Have a family history of HC.

Siobhan Huggins
Admin
Siobhan Huggins(@siobhanh)
4 years ago
Reply to  ryan

Hi, ryan. A few questions –
You mention that your small LDL was 612, but what was your total LDL-P? I often notice that it seems to scale with the total number of particles, so was your LDL-P – say – 2500 or so?
Likewise with apoB I would expect this to go up. Each LDL particle has an apoB on it (it’s the “skeleton” which give gives the particle structure), so as LDL-P goes up so should apoB (although there are other circumstances where it could as well).
HDL going up, and triglycerides going down is actually exactly what I would expect for someone doing low carb – and this was reflected in the recent virta health study, as well.
Lastly, were you 12-14 hours fasted for this test? Sometimes results can be odd if fasted for too long or not long enough.

As for the LDL going up in the first place, as you hinted you may be a hyper-responder, especially if you’re on the leaner side. Perhaps it would help to look at the over all context, such as look at fasting insulin and hs-CRP (a marker of inflammation).

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