Lean Mass Hyper-responders

IMPORTANT UPDATE: Please visit our new paper on Lean Mass Hyper-responders published in Current Developments in Nutrition (https://doi.org/10.1093/cdn/nzab144)

Lean Mass Hyper-responder Overview

Generally speaking, Lean Mass Hyper-responders (LMHRs) have the following lipid profile:

  • LDL of 200 mg/dL (5.17 mmol/L) or higher
  • HDL of 80 mg/dL (2.07 mmol/L) or higher
  • Triglycerides of 70 mg/dL (0.79 mmol/L) or lower

This pattern was first discussed in the original Are You a Lean Mass Hyper-responder articles from July of 2017.

Common Characteristics of a Lean Mass Hyper-responder

  • Often lean, with low body fat (≤20% men, ≤23% women).
  • Usually moderate to very fit. Many are very athletic.
  • Usually very low carb (typically <25g net carbs)

Other possible commonalities:

  • Often lower BHB (Blood Ketones) levels than sedentary low carbers (often 0.3-1.0 mmol/L)
  • Generally higher fasting glucose, possibly through adaptive glucose sparing (often 90-105 mg/dL)
  • Greater difficulty doing multi-day fasting

Why This Profile Might Make Sense

On this blog and through many articles I discuss the Lipid Energy Model. Fairly soon I’ll have a streamlined post that will tie it together for lay people. For now, you may want to watch the linked video above as I describe it briefly.

Or for a more layperson-friendly series, check out A Simple Guide to Cholesterol on Low Carb

Also check out our FAQ as well for more information.

Is This Profile Risky

The short answer is: we don’t know.

That said, the anecdotal data looks exceptionally good so far. I’m currently working with several different people across many disciplines to initiate studies with LMHRs in particular, as I think they may hold the answer to some very important questions on the subject of cholesterol.

Another great article that discusses this in greater depth is Cholesterol Endgame?

Facebook Group

We also have a LMHR Facebook group that we invite everyone to join, whether you are a LMHR or just interested in the research.

If you have further questions or thoughts on LMHRs, go ahead and post your comment at our Questions thread.