Talking Cholesterol, Oxidation, Hyper-responders, and Risk with Paul Saladino

Had a great conversation with Paul. Not surprisingly, lots of topics came up with regard to the risk, my current oxLDL vs oxPL experiment, my recent research regarding FH receptors, etc.

I did mention tendon xanthomas and why it is that I’m looking very closely for it with hyper-responders in general, and LMHRs especially (as you’ll note from my many posts requesting this information)

And of course, I mention the LMHR study at several points, including my pointing to how I feel those skeptical of LMHR having high LDL should be the most proactive in helping us make this happen.

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Chris
Chris
18 days ago

Hi Dave, have you seen Ivor’s interview with prof. Subbotin? https://www.youtube.com/watch?v=jv9qXM2qLxo
Arteries inflammation seems to be the key – no inflammation and LDL makes no harm – inflame artery and you will start to deposit LDL where you shouldn’t – possible mechanism is explained in the video

Last edited 18 days ago by Chris
Andy Roberts
Andy Roberts
18 days ago
Reply to  Chris

Interesting Chris. I recently did an experiment for about 2 months whereby i increased my fat and salt on a keto diet while measuring arterial stiffness (pulse wave velocity). during this time the pwv spiked to almost levels of suboptimality. When i reduced again they have started to settle. i have also started to reduce my fat ratio for protein and am re-gaining the lost lean mass. BP remained low throughout this experiment. Only symptoms that arose were variable vitality and clear headedness and increased forgetfulness. There are a lot of people in the keto community doubling down on fat and salt who don’t have sight of metrics such as pulse wave velocity who could be storing up signifcant long term issues.

Chris
Chris
17 days ago
Reply to  Andy Roberts

Truly speaking I am a bit confused with all the information available (I do have Peter Attia on my readings list…). Some time ago I was looking for information about high fat diet and arterial stiffness and I have found nothing (not sure about the keywords now). I am starting to track HRV next week (planning on 24/7 measurements using Polar H10) to somehow track inflammation as I saw studies showing HR metrics correlated with CRP.

Andy
Andy
17 days ago
Reply to  Chris

Great call Chris, I am going to purchase too.. throw in a CAC scan as well and that’s 3 very useful metrics that should be very useful context for any cholesterol readings.

Siobhan Huggins
Admin
17 days ago
Reply to  Chris

We’re both familiar with Ivor, as well as Subbotin’s work. 🙂
It’s definitely interesting stuff.

Wendy mobley
Wendy mobley
18 days ago

I need BIG time advise. I am 52 female active but not gym active. Post menopause. I eat fatty meat, lots of eggs, some organ meat and some veggies my cholesterol is very high. I don’t drink or smoke. 2 cups black coffee daily
HDL 88
LDL 447.2
Trig 124
TTL 560
Dr wants me on medication and fruits and veggies. I refused for now but I’m scared and I don’t have anyone to advise me around here where I live.

Siobhan Huggins
Admin
13 days ago
Reply to  Wendy mobley

Hi, the higher than expected triglycerides paired with the high/normal HDL is interesting. Were you 12-14 hours water-only fasted for this test? If so, you may want to check out this post as it has other possibilities. Although I’m not a doctor and can’t give medical advice, often this type of profile tends to originate from something confounding the test.

Sebastian
Sebastian
17 days ago

Dr. Paul Saladino says in the podcast that his LDL particle number is 3283 nmol/L. I wonder, if he had APOE4, would it still be safe to have a high LDL particle count?

Siobhan Huggins
Admin
12 days ago
Reply to  Sebastian

I think this would be up to the individual whether they’d be comfortable with it or not, given their context. Lean Mass Hyper-responders have yet to be studied longterm, let alone specifically ApoE4 carrying LMHRs. But, from what I’ve heard about apoE4, I’ve seen the importance of metabolic health over the longterm being emphasized (from e.g. Amy Berger). Beyond that, I don’t know that we know.

Truthseeker .
Truthseeker .
16 days ago

Hi Siobhan/Dave
I came across this study and would love your imput or thoughts,
as I have FH and grandchildren.
I also have extremely high LDL and LP(a)…. Long-standing heart disease culminating
With quadruple bypass in june this year.
There is a suspicion of a clotting disorder but because of the scamdemic, Dr’s, Cardio clinics seeing
No patients no tests. I’m in UK

https://www.nejm.org/doi/abstract/10.1056/NEJMoa1816454

Siobhan Huggins
Admin
12 days ago
Reply to  Truthseeker .

Hi – I honestly don’t spend much time on most drug studies as they’re not really in my area of interest. However, I’m betting David Diamond (@LDLSkeptic on Twitter) would likely have commentary given it’s a pet topic of his.

Truthseeker .
Truthseeker .
12 days ago

Thanks for your reply Siobhan, I will try that route or possibly McKendrick.
One more question if you don’t mind
I know in the early days of cholesterol code IIRC Dave And your self posted studies
and study rebuttals…. Did you ever come across any studies Connecting FH and
Blood coagulation disorders for higher heart disease death rates in people with FH.
UFFE RAVNSKOV pointed to this year’s ago in his book (The Cholesterol Myths)…
.. I’m not sure if this was ever studied, and if you have any links or posts I would be very
grateful.
Over the years and several bloodtests there have always been some ** markers,
Prothrombin time etc, on tests and nothing was ever mentioned by doctors or
cardiologists. This only came to my attention as I dug a bit deeper and understood
a bit more.
Thanks in advance☺️

Siobhan Huggins
Admin
7 days ago
Reply to  Truthseeker .

Yeah I think this is something that has been brought up by David Diamond. There’s this one by Uffe and David Diamond, for example. Off the top of my mind, I’m reminded by this one as well which mentions insulin, t-PA, and PAI-1. To be sure, I don’t know how much this may play in, or if there are other factors that may be more important – but yes, I have seen it brought up occasionally as something that may be playing a part, and that should be investigated more.

Truthseeker .
Truthseeker .
16 days ago

Just to add some info.
First 2stents age 39 so I’m assuming HD starting much earlier,
went on to have numerous stents over the years up until august 2015
7 or 8 stents in all.
2 heart attacks…. 1in august 2015 (resulting in 3 stents)
Second in December 2019, angiogram revealed that too much damage so only solution
was urgent bypass surgery.
My diet is not unhealthy but I under eat, never really get hunger signals or thirst signals.
I also have had anxiety and depression, I seem to have learned helplessness.
Not very active age 63

Duanev
Duanev
4 days ago

I started listening to Ali Bitter man’s youtube discussion with Dave (I’m only 30 mins in), but am curious, Ali wants Dave to take a stance on “will high LDL in the presence of high HDL and low Trigs increase risk for atherosclerosis” … and I’m like why doesn’t Dave counter with is the LDL oxidized or not? Oxidized (damaged) LDL isn’t recognized by the liver’s receptors and thus lingers in the blood adding ROS stress (if I understand correctly) – so if high amounts of damaged LDL then yes to inc risk, else probably not, or am I missing something. Or was that debate prior to Dave’s oxLDL studies?

Duanev
Duanev
4 days ago
Reply to  Dave

Ah thanks, and I need to get to the above recording too, which has to be more productive Ali’s agenda didn’t help deconvolve things either (why are we introducing brand new mind psych terminology in a bio debate?!) – but I want to say great work handling his (and other Twitter doc’s) challenges – your demeanor is inspirational sir!

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