Dec 17

Incredible! New Contributor Will Match CSF Funds When Reaching $100,000!

[This is a sharing of the original article from our sister CitizenScienceFoundation.org site]

Click Here to Contribute to the Project

I’m beyond ecstatic to announce a new anonymous donor has come forward and is offering to match our total donations once we reach $100,000!

As of this writing, we’re sitting at $66,150, which means we have just $33,850 to unlock the match.

In other words, every $1 you contribute now is worth $4!

The Dream Scenario of 100 LMHRs

It was barely two months ago on the stage of Low Carb Houston that I announced the start of this project and that my dream scenario would be getting 100 Lean Mass Hyper-responders to participate. At 100, we’d have a very powerful population given the effect size reflected in their LDL levels.

Our back-of-the-envelope math suggests all the testing we wish to do (CT Angiogram, CIMT, CAC, etc) will probably be around $2,000 each. Thus, $200,000 gets us there.

Please Contribute and Share

We’ve come so far, so fast — but we couldn’t pull this off without your help. Please continue to contribute and share to help us cross that $100,000 line!

Thanks again for your support.

Click Here to Contribute to the Project

Dec 12

End of Year Thanks – 2019

While I know Thanksgiving has passed, I tend to think of the many things to be thankful for near the end of the year. And make no mistake, I have a pretty long list.

Thank you, Members and Patrons

There’s one reason above all others that we’re able to keep the lights on and focus entirely on this research — direct contributions and membership. Both Siobhan and I live with very low overhead, but we can both correctly point out our bills are paid by individuals contributing directly to our work (including a handful of very generous individuals in particular).

Many hit that “Donate” button in the upper right corner of this website to do a one time donation. Donations range from small to large, but all of them matter — a lot, actually.

And many have gone further to sign up to our membership, Patreon accounts (mine, Siobhan’s) for monthly recurring funding. And some have setup a recurring monthly donation in PayPal to help us out.

When I started this research and website four years ago, I intended to never take any compensation from a business entity, have any affiliates, or truly any quid pro quo that could influence my research. YOU have made that possible! You’re all making this true #CrowdSourcedScience.

Thank you, Citizen Science Foundation Contributors

I’m going to level with you, I genuinely had no worldly idea whether the launch of the LMHR (Lean Mass Hyper-responder) Project under the Citizen Science Foundation (CSF) would be a success or a terrible failure. They recommend kickstarters have no more than $50,000 as a goal given just how hard it is to raise that much — and that usually has a product or service that directly benefits backers personally. Many (including myself) were very unsure if this would work for a data collection project, much less one that will take five years to complete.

Your contributions exceeded all my expectations. Truly.

While it’s true I’m hoping to get to the magic number of 100 LMHRs, and at around 2k/LMHR for testing, I’m blown away that we’re already 1/3rd of the way there ($66k as of this writing) in less than two months.

(If you want to learn more about our next steps, be sure to check out our roadmap at the CSF website.)

Speaking of which — Thanks to Spencer Nadolsky

Nothing has surprised me more than the lack of interest in doing a follow up study on LMHRs, given what a truly unique profile they present as a group. To date, Spencer is the only exception I know of. He wants to study them and understand if indeed we’ll see the same progression of atherosclerosis we observe in genetic familial hypercholesterolemia given they are the only population with comparable levels of LDL.

Spencer is hypothesizing the opposite outcomes than I am regarding the project – but that’s a feature, not a bug. As always, I value both contrarian views and transparency highly. It’s easier to achieve when each major side of a divide has excellent representation on the team moving forward.

And of course, Thanks to Tommy Wood

Tommy and I have actually be collaborating for a while. He and his team have helped me get NHANES in hand for my analysis. And we’re working on the Lipid Energy Model paper (albeit a bit slower than originally intended).

But in particular, his coming onboard the LMHR Measurement Project is a real game changer for us. He’ll be helping us take the project to the next level as you’ll see in the coming months.

Most of All, Thanks to The Mrs.

My wife has been unbelievably accommodating and supportive of this research. A little over a year ago she started an ambitious points and miles project that had us constantly switching in and out credit cards and doing our purchases during targeted time periods, hitting multiples to maximize values, and joining (and also canceling) a number of different programs to get the best deals.

All these efforts paid off as she has accomplished setting up an around-the-world series of trips to help with the documentary I’m filming in 2020. The vast majority of this trip is on the points and miles, the remainder is on her dime as a contribution to this research endeavor. I can’t possibly thank her enough in person, much less a blog post. But I suppose I’ll have plenty of time ahead to keep trying. 🙂

Nov 23

#CholesterolScience with Kevin Bass

Many of you who follow my work know I actively pursue challenge. Part of that process of engagement is in initiating contact with people who may not only disagree with me — but might be very polarizing for many in the low carb community. Certainly Kevin Bass fits this description.

I had booked Kevin for an appearance with #CholesterolScience a few months ago, but between then and the show we recorded yesterday, a controversy arose that involved Dr. Ken Berry. We address this briefly at the beginning of the interview.

All in all, there were many things I liked about this interview. It was a Friday night and we were both a bit loose and not always as articulate as our A Game might allow, but that also created a much more stream-of-consciousness kind of honesty that came through at multiple times.

Reference Links

We mentioned several things throughout the broadcast that I’ll link below.

Names mentioned:

NHANES Material

LDL Level Changes during Inflammation

Kevin provided this study — The Effect of Inflammation and Infection on Lipids and Lipoproteins

While I haven’t had a chance to read the study in full, I can say that it appears this had more to do with the serum levels of lipoproteins, not specifically the production. The blood levels don’t tell us much regarding production without knowing the other side of the ledger regarding how much is subtracted via endocytosis, scavenger receptor removal, etc.

Nov 15

Three weeks – $50,000 Funding Benchmark Reached and Counting

Click here to contribute to the project

I’m extremely proud to announce we met and surpassed the $50,000 benchmark I set as our starting point at Low Carb Houston exactly three weeks ago today.

Words cannot express the level of thanks I have for this community coming together and driving this science forward.

Please keep those donations coming. By our rough estimates, each $2,000 will cover us for one LMHR measured. And as I also mentioned in Houston, my dream would be for us to get to 50, or even 100 LMHRs tracked. To be sure, that may be a stretch goal… but as of right now, it’s not so far away.

As of this writing, we’re already at $56,232. Part of this new surge has been boosted by the new video I released a couple days ago, which has helped spread the message and reach new audiences.

Yet the most powerful MVPs are the people who actively spread the word far and wide — you might be one of them. Don’t just contribute, share!

Davoprotein

Lastly, I made a challenge with the community that if we actually reach all the matching funds for our Anonymous Donor ($25k for Nov), that I’d make a lipoprotein costume and run in it for the 10k I’m in this Sunday. As of right this moment, we’re just $3,423 from hitting that goal. Thus, I’ve already started making it, given the velocity of donations so far, I might very well be wearing it in two days!

The community has until midnight tomorrow to make this happen. And while it would be definitely be a much more difficult jog (I’m already woefully undertrained), it would definitely be worth it for me. Plus it would be pretty cool story, all in all.

Again, Thank You

One more time, let me just say thanks. I have more faith in citizen science today than ever before. The magnitude of progress to this benchmark has exceeded even my most optimistic assumptions.

You made it happen.

Nov 05

Travel Schedule and Signup for Documentary Filming

From January 7th to February 29th we’ll be traveling around the world (literally) and filming a series of interviews on the science of lipids and cholesterol along with the emerging research on its relation to low carb diets and metabolism (which is my central focus here at CC).

We actually have a sophisticated setup with several cameras, lights, mics, and tripods. We hope to gather quite a lot of footage over these eight weeks.

Who We’re Interviewing and How to Join

First and foremost, please check the schedule below to confirm we’re coming to your city and country when you would be available to be interviewed (details below). Please also be aware that we expect a lot of inquiries and will likely be unable to interview the majority of those applying. With that said, we hope to capture many interesting stories and opinions from medical and non-medical professionals alike.

We’re looking to interview three main groups of people.

  1. Lipidologists, Cardiologists, and researchers in the field of lipids and/or cardiovascular disease. It’s important to get perspectives from every side represented in the documentary. So whether you are pro-lipid hypothesis, a skeptic, or somewhere in between, we’d love to have you on.
    • If this category describes you and you’re interested in being interviewing for this documentary — please sign up here.
  2. Low carb “Hyper-responders” and “Lean Mass Hyper-responders” – those who have had a pronounced increase in their total and LDL cholesterol since adopting the diet. We’re interested in a variety of stories and opinions on what these means to the individual.
    • If this category describes you and you’re interested in being interviewing for this documentary — please sign up here.
  3. Doctors who have low carb patients and how they are treating the rising number of cases for hyper-responders.
    • If this category describes you and you’re interested in being interviewing for this documentary — please sign up here.

China and Japan

DateDayCityInterview Times
7-JanTuesShanghai, China5pm-onward
8-JanWedShanghai, Chinauntil 6pm
9-JanThursShanghai, Chinaall day
11-JanSatMacau, Chinaall day
12-JanSunMacau, Chinaall day
13-JanMonMacau, Chinaall day
14-JanTuesHong Kong, Chinauntil noon
16-JanThursOkinawa, Japan1pm-9pm
18-JanSatShanghai, China2pm-onward

Malasia, Tailand, and Singapore

DateDayCityInterview Times
21-JanTuesKuala Lumpur, Malaysia7am-3pm
22-JanWedPhuket, Thailand10am-10pm
24-JanFriSingaporenoon-onward
25-JanSatSingaporeall day
26-JanSunSingaporeall day

Australia and New Zealand

DateDayCityInterview Times
28-JanTuesMelbourne, Australiaall day
29-JanWedMelbourne, Australiaall day
30-JanThursSydney, AustraliaTBD
31-JanFriSydney, Australiaall day
1-FebSatSydney, Australiaall day
2-FebSunSydney, Australiauntil noon
5-FebWedBay of Islands, New Zeland8am-6:30pm
6-FebThursTauranga, New Zeland7:45am-5pm
7-FebFriNapier, New Zeland10am-5pm
8-FebSatWellington, New Zeland7am-3pm
9-FebSunDunedin, New Zeland9am-5pm
13-FebThursPerth, AustraliaTBD

United Arab Emirates

DateDayCityInterview Times
15-FebSatDubai, UAEall day
16-FebSunDubai, UAEall day

Northern Europe

This visit will be a bit more variable. We may be visiting a number of northern European cities depending on the availability of certain key interviews. (See below)

DateDayCityInterview Times
17-FebMonLondon, United Kingdom2pm-onward
18-FebTuesWales, United Kingdomall day / TBD
19-FebWedNorthern United Kingdom*all day / TBD
20-FebThursNorthern United Kingdom*all day / TBD
21-FebFriLondon and Northern Europe*all day / TBD
22-FebSatLondon and Northern Europe*all day / TBD
23-FebSunLondon and Northern Europe*all day / TBD
24-FebMonLondon and Northern Europe*all day / TBD
25-FebTuesLondon and Northern Europe*all day / TBD
26-FebWedLondon and Northern Europe*all day / TBD
27-FebThursLondon, United Kingdomall day / TBD
28-FebFriLund, Swedenall day / TBD
29-FebSatCopenhagen, Denmarkhalf day

* We are looking at the following candidate cities as potential areas we’ll visit:

  • Brussels
  • Paris
  • Zurich
  • Amsterdam

* We’re also likely to visit the following cities inside the UK:

  • Liverpool
  • Cardiff
  • Glasgow
  • Edinburgh

What the Documentary is and When it Will Be Released

While we know the subject matter of what we’re filming, the exact nature of its final format when it will be released is yet to be determined. We’re seeking to capture many, many hours of interviews that help tell the story of how we got this this point of understanding with cholesterol and risk, how hyper-responders from the low carb movement have opened new questions, and what the next steps are for the science in this field.

This may be a feature length documentary, or it may be a series of shorter segments tackling each topic in succession. Regardless, it won’t change our efforts to capture as much footage as we can for experts, doctors of low carb patients, and hyper-responders from around the world. This is a story that certainly needs to be explored.

Extraordinary Thanks to the Mrs

I have to take a moment to thank the Mrs for her tireless efforts in researching and capturing a huge cache of points and miles that are covering the vast majority of this trip. It was a year-long project and required a lot of sophisticated credit card swapping, targeted timing for purchases, and lots and lots of reward programs. That… plus we’re cashing in prior points and miles from before this year.

Update to the Film Project will be Posted Here

Lastly, be aware that this blog post will be where updates are posted — so bookmark it now. These updates will likely be added at the top of this page in reverse order of the timing so you only have to scan the top to know if there is something new to report.

And as always, I’ll be actively posting updates on Twitter as well @DaveKeto

[UPDATE 2019-12-23: We are looking at eight candidate cities for Northern Europe beyond London, which are marked as footnotes. See the sections above marked *]

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