Now with 28 NMRs, Low Carb USA, and Upcoming Part IV

Greetings again, my friends! These past four weeks have been pretty packed and my next three weeks will be no different. That said, I’ve managed plug in a lot more NMRs due to the experiment I’ve been conducting which involved another week of successive blood draws, bringing the total to a whopping 28! In so doing, it appears the “diversion” I wondered about in Part III of the series appears to be a one-off. (See graphic below)

Tonight I’ll be flying to San Diego to attend the Low Carb USA conference this weekend. I’m excited to update a number of the doctors I’m typically connecting with over Twitter and email. I already have five meetings and am getting worried about my bandwidth impacting my lecture attendance. It’s gonna be busy!

I have completed a fairly involved experiment a couple weeks ago which I’ll be previewing at the conference to a number of people, and for which I’ll have posted here at the blog before August 8th (as Part IV of the series) to coincide with my discussing it on Jimmy Moore’s Living La Vita Low Carb Show. Needless to say, I’m extremely excited to share the results.

dietary_fat_to_cholesterol_inversion

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K. Renee Lee
K. Renee Lee
3 years ago

Dave,
It was great meeting you at Low Carb USA/Apoe4 meetings. I also enjoyed you on ZDogg. I have been doing keto for 2 yrs now. I told you I would send you my NMR results. I had them done after my Apoe 3/4 discovery in May. In my constant search for information I have also found that I am homozygous for the APOA2 gene. (GG)
I really know nothing about this except everything I read says I should stay away from saturated fat. And that it effects the HDL. Anything you can share with me on this would be great.

NMR: 5/27/17 (labcorp)

LDL-P 1797
LDL-C 146
HDL-C 51
Triglycerides 93

Particle concentration & size
HDL-P (total) 35.1
small LDL-P 876
LDL size 20.8

LP IR 40

Thank you so much for your research.

A. Muk
A. Muk
1 year ago
Reply to  K. Renee Lee

I am also having a hard time finding ways to interpret my NMR results.

NMR: 7/17/10 (labcorp)

LDL-P 2352
LDL-C 274
HDL-C 56
Triglycerides 174

Particle concentration and size
HDL-P 25.9
Small LDL-P 276
LDL Size 22.3

LP IR <25

I am really concerned about the number of particles. Everything I read says the result is alarming!

Thanks so much for this site. It helps demystify what is going on in our bodies.

Eileen Johnson
Eileen Johnson
1 year ago

Dave, where do we find a place to interpret the data from our NMR tests?

Ana Smith
Ana Smith
19 days ago

Not sure how to interpret my NMR results.LDL-P=3272; small LDL-P=1287; LDL Size=21.1; LP-IR Score=<25; HDL-P=38.8.
LDL-C=255;HDL-C=86;TGL=53;TOTAL CHOL=362.
I’ve been told because my HDL is so high & my TGL is so low, that I was at low risk for CVD. However, the number of LDL particles is so high yet my particle size is on the low side.
These are very mixed results. Don’t know how to interpret.Help!
By the way my doctor didn’t know what to do with these results. I requested that she order this test.

Siobhan Huggins
Admin
15 days ago
Reply to  Ana Smith

Hi – I’m not a doctor and can’t give medical advice, but I can offer my opinion where I think it may be of interest.
It is interesting that there’s some slight discordance between LDL-C and LDL-P despite high HDL and low triglycerides.
From what we’ve seen, LDL-P is usually LDL-C x10 +/- 15% or so, and you’re just a tad above that (e.g. “slight discordance”), and small LDL-P is typically 30% or less of total LDL-P, and you’re at about 40%.

Although these are only slightly off of what I’d expect, if it were me in the same position, I’d likely want to explore a bit further as there are a couple things that might cause this that can come up in daily life prior to testing I’d want to rule out first.

For example, as Dave has discussed LDL-C tends to follow a three day window, while LDL-P tends to follow a 3 day window with two day gap (5 day total) surrounding fat intake. So dietary changes during this period can impact, as one is on a slight delay behind the other one.

So, if it were me, I’d want to think back to the 5 days leading into the test, and investigate the context there.
1) Were you 12-14 hours water-only fasted leading into the blood draw? E.g. no coffee, no tea, no caffeine – water only
2) Did you fast for 24+ hours at any point?
3) Did you have any big/intense (compared to a sedentary person) exercise events in the days leading into the test?
4) Was there any change to your diet over this period, beyond fasting? E.g. did you eat unusually more or less than usual during the five day lead in?

These questions should help rule out common confounders that we’ve seen that cause this type of result. If you got any, it can also help to look at other tests you got at the same time (if you got other tests from the same time period/blood draw). Things like inflammatory markers, etc can provide additional context.

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