1:30 The Innate immune system and the adaptive immune system – what’s the difference?
3:25 The innate immune system and bacteria
8:00 How does immunity relate to atherosclerosis?
13:34 A link between atherosclerosis and diabetes/autoimmune diseases?
16:35 Absorption in the gut, and intestinal permeability
22:10 Nick and Nathan’s hypothesis
24:30 Dave’s thoughts on the hypothesis – is there anything to support or contradict the hypothesis?
28:24 The nuance of atherosclerotic plaque progression
Book mentioned: Natural History of Coronary Atherosclerosis by Constantin Velican
31:16 Multiple initiators of atherosclerosis – do they all have the same root cause?
33:00 Does atherosclerosis progression and regression come down to gateway keeping?
35:00 High frequency testing to challenge the hypothesis – Dave’s proposal
36:45 Atherosclerosis as a post-prandial phenomenon and ‘binge-ury’
40:00 Proposed testing of the hypothesis and follow-up questions regarding intestinal permeability
43:20 Learning from high carb experiments and aftereffects
49:10 The impact of the microbiome, and issues with testing in humans
51:00 Devil’s advocate – what about LDL?
1:00:00 Drugs used to prevent heart disease, lipoproteins, and how they relate to the endotoxin hypothesis
1:03:39 The disconnect in research on lipoproteins and immunity
1:08:34 How drugs relate to the endotoxin theory (cont)
1:10:04 If the drugs impact disease progression and all-cause mortality – why not take them?
1:11:32 Lean Mass Hyper-responders – do Nick and Nathan feel caution is needed to lower their LDL?
Term used: For more information on Lean Mass Hyper-responders see the page on CholesterolCode.
1:13:53 The importance of a long-term follow-up study on Lean Mass Hyper-responders
Nick/Nathan’s Patreon: https://www.patreon.com/rootcausinghealth