0:00 Intro
0:30 David Diamond’s health and history – how did he get to where he is now?
3:22 Dr. Diamond’s previous research involving stress and nutrition, and further investigation of the impacts of a “high fat” versus “ketogenic” diet
Study mentioned: Combination of high fat diet and chronic stress retracts hippocampal dendrites.S
6:00 Further investigation into Dr. Diamond’s high triglycerides on a standard American diet, and how he tackled the problem
9:40 David’s current bloodwork and other health markers
11:47 The curiosity of people who change their committed mind
14:30 David’s thoughts on the data on mortality in Norway during WWII

20:50 Morrison study – were improvements from the diet, or the lifestyle?
Study mentioned: Reduction of mortality rate in coronary atherosclerosis by a low cholesterol-low fat diet
23:20 Do ketogenic diets have to be high meat diets? What is an ideal human diet?
25:56 Dean Ornish – changing lifestyle, lowering stress and its impact on health.

30:00 What does David say to randomized control trials of vegan vs omnivorous diets being “too hard”?
32:57 Dave’s experience with vegans who have high triglycerides
35:00 Are plant foods and fiber inherently healthy?
38:40 The use “overuse” of paradox in the medical and nutrition field – the paradox of high fat/high meat consumption in indigenous populations and low rates of heart disease
44:07 Devil’s Advocate intro
44:26 Wouldn’t it be fair to say that there’s enough evidence that LDL, in itself, causes heart disease?
Study mentioned: Inborn coagulation factors are more important cardiovascular risk factors than high LDL-cholesterol in familial hypercholesterolemia.
Study mentioned: Lack of an association or an inverse association between low-density-lipoprotein cholesterol and mortality in the elderly: a systematic review.
Study mentioned: Mortality among patients with familial hypercholesterolemia: a registry-based study in Norway, 1992-2010.
54:50 The vast majority of experts agree on the need to lower LDL – shouldn’t we trust the experts?
Statement mentioned: Statin Safety and Associated Adverse Events: A Scientific Statement From the American Heart Association
58:55 Submitted questions intro
59:00 How do PCSK9 inhibitors work?
1:04:19 Is two years sufficient to see outcomes from cholesterol lowering therapy? What do the current studies show for effectiveness?

1:11:50 What about all-cause mortality and cholesterol levels?
Study mentioned: Familial Hypercholesterolemia: A Genetic and Metabolic Study.
1:14:40 Discussion on the effects of cholestyramine for use in cholesterol lowering

Study mentioned: Corn Oil in Treatment of Ischaemic Heart Disease
1:24:24 Can a Low Carb High Fat diet lower the proportion of small dense LDL in people with Familial Hypercholesterolemia?
1:28:28 What are David’s thoughts on taking statins while on keto?

1:35:00 If LDL isn’t a strong indicative marker of risk, what does David suggest people look at instead?
1:35:57 Is it how often your blood sugar spikes per meal, or just that it spikes?
1:38:10 Thoughts on curcumin and berberine to reduce blood sugar and cholesterol?
1:39:34 Do people on Low Carb High Fat/keto have slightly fatty livers?
1:44:00 Outro and how to reach David Diamond
Twitter: @LDLSkeptic
Facebook: David Diamond
Brilliant show! Thanks for putting it all together, Dave and Sibhon – I am really benefiting from this series. I have shared many of David Diamond’s presentations with friends and family – this is a great discussion to add to my list of shareable resources.
I love how strident he is regarding “processed”
and “whole” foods. These meaningless terms
are bandied about in the LCHF/keto community
to the detriment of understanding the issues.
Dave/Siobhan. Any chance of you making transcripts of these interviews? There is a ton of good information in them that would be easier to re-find in a text format.
We’re already too swamped as it is. Maybe you can help us find a solution. 😉