#CholesterolScience Show – With Dr. David Diamond

0:00 Intro

0:30 David Diamond’s health and history – how did he get to where he is now?

3:22 Dr. Diamond’s previous research involving stress and nutrition, and further investigation of the impacts of a “high fat” versus “ketogenic” diet

Study mentioned: Combination of high fat diet and chronic stress retracts hippocampal dendrites.S

6:00 Further investigation into Dr. Diamond’s high triglycerides on a standard American diet, and how he tackled the problem

9:40 David’s current bloodwork and other health markers

11:47 The curiosity of people who change their committed mind

14:30 David’s thoughts on the data on mortality in Norway during WWII

20:50 Morrison study – were improvements from the diet, or the lifestyle?

Study mentioned: Reduction of mortality rate in coronary atherosclerosis by a low cholesterol-low fat diet

23:20 Do ketogenic diets have to be high meat diets? What is an ideal human diet?

25:56 Dean Ornish – changing lifestyle, lowering stress and its impact on health.

30:00 What does David say to randomized control trials of vegan vs omnivorous diets being “too hard”?

32:57 Dave’s experience with vegans who have high triglycerides

35:00 Are plant foods and fiber inherently healthy?

38:40 The use “overuse” of paradox in the medical and nutrition field – the paradox of high fat/high meat consumption in indigenous populations and low rates of heart disease

44:07 Devil’s Advocate intro

44:26 Wouldn’t it be fair to say that there’s enough evidence that LDL, in itself, causes heart disease?

Study mentioned: Inborn coagulation factors are more important cardiovascular risk factors than high LDL-cholesterol in familial hypercholesterolemia.

Study mentioned: Lack of an association or an inverse association between low-density-lipoprotein cholesterol and mortality in the elderly: a systematic review.

Study mentioned: Mortality among patients with familial hypercholesterolemia: a registry-based study in Norway, 1992-2010.

54:50 The vast majority of experts agree on the need to lower LDL – shouldn’t we trust the experts?

Statement mentioned: Statin Safety and Associated Adverse Events: A Scientific Statement From the American Heart Association

58:55 Submitted questions intro

59:00 How do PCSK9 inhibitors work?

1:04:19 Is two years sufficient to see outcomes from cholesterol lowering therapy? What do the current studies show for effectiveness?

1:11:50 What about all-cause mortality and cholesterol levels?

Study mentioned: Familial Hypercholesterolemia: A Genetic and Metabolic Study.

1:14:40 Discussion on the effects of cholestyramine for use in cholesterol lowering

Study mentioned: Corn Oil in Treatment of Ischaemic Heart Disease

1:24:24 Can a Low Carb High Fat diet lower the proportion of small dense LDL in people with Familial Hypercholesterolemia?

1:28:28 What are David’s thoughts on taking statins while on keto?

1:35:00 If LDL isn’t a strong indicative marker of risk, what does David suggest people look at instead?

1:35:57 Is it how often your blood sugar spikes per meal, or just that it spikes?

1:38:10 Thoughts on curcumin and berberine to reduce blood sugar and cholesterol?

1:39:34 Do people on Low Carb High Fat/keto have slightly fatty livers?

1:44:00 Outro and how to reach David Diamond

Twitter: @LDLSkeptic

Facebook: David Diamond