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Nov 10

Carotid Artery Update

In case you were keeping track, I’ve been getting a CIMT twice a year since starting in ’16. I just got my fourth one yesterday and was certainly curious to see what would come back.

Early on in my cholesterol education I came across an article by Rakesh C. Patel, Does LDL-P Matter?. He had this to say about the test:

My workhorse disease detection is Carotid Intima Media Thickness (CIMT). This test simply put, measures the “lining” of the carotid artery via ultrasound. The thicker the lining is, the greater the risk. It is also a way to assess for plaque (atherosclerosis) of the artery. Having plaque means you have atherosclerosis. I believe it is a significantly better way of looking at risk because we are looking for the actual pathology (1,2).

Given the last two times my thickness decreased on both sides, I figured I’d probably plateau or increase at least a little by this point.

Nope. Looks like the streak is continuing so far…

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Guesting on the Peter Attia Drive (4 of 5) – Energy Status, Risk, Testing the Hypothesis » Cholesterol CodeDaveAbhishek+AnandAbhishek AnandAndy Recent comment authors

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Bob Niland
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Have you done a baseline and any follow-up CT calcium scans?

In the program I contribute on, CIMT is considered useful and convenient, if only because you can get it run as often as you like, and cheaply, but the dispositive test is the CT calcium scan, or CAC (coronary arterial calcium), yielding an Agatston calcium score.

It is radiation, so doing it more often than annually is not encouraged. Malik, Zhao & Budoff just yesterday published another paper on the utility of it. Available without doctor’s order for $100 in many places.

And as with CIMT, it is possible to slow, arrest and reverse calcium scores, although you are unlikely to hear that from consensus practitioners, because they don’t know how to do it, think the opposite is true, and tend to prescribe diets and meds that just increase the score. Consequently, they are reluctant to order it.

Mike
Guest
Mike

I think density-volume information is likely to be a better indicator of risk than the simple Agatston. My test was read by Dr. Budoff but unfortunately he only gave me the Agatston number and I have been unable to get the full information. The density relates to plaque stability and apparently increase with the amount of exercise. Since I swim regularly and have a fairly high Agatston I would like to see the alternative calculation but it will have to wait until my next assessment.

Coronary Artery Calcium Volume and Density: Potential Interactions and Overall Predictive Value: The Multi-Ethnic Study of Atherosclerosis.
ncbi.nlm.nih.gov/m/pubmed/28797404/
Abstract

OBJECTIVES: This study sought to determine the possibility of interactions between coronary artery calcium (CAC) volume or CAC density with each other, and with age, sex, ethnicity, the new atherosclerotic cardiovascular disease (ASCVD) risk score, diabetes status, and renal function by estimated glomerular filtration rate, and, using differing CAC scores, to determine the improvement over the ASCVD risk score in risk prediction and reclassification.

BACKGROUND: In MESA (Multi-Ethnic Study of Atherosclerosis), CAC volume was positively and CAC density inversely associated with cardiovascular disease (CVD) events.

METHODS: A total of 3,398 MESA participants free of clinical CVD but with prevalent CAC at baseline were followed for incident CVD events.

RESULTS: During a median 11.0 years of follow-up, there were 390 CVD events, 264 of which were coronary heart disease (CHD). With each SD increase of ln CAC volume (1.62), risk of CHD increased 73% (p < 0.001) and risk of CVD increased 61% (p < 0.001). Conversely, each SD increase of CAC density (0.69) was associated with 28% lower risk of CHD (p < 0.001) and 25% lower risk of CVD (p < 0.001). CAC density was inversely associated with risk at all levels of CAC volume (i.e., no interaction was present). In multivariable Cox models, significant interactions were present for CAC volume with age and ASCVD risk score for both CHD and CVD, and CAC density with ASCVD risk score for CVD. Hazard ratios were generally stronger in the lower risk groups. Receiver-operating characteristic area under the curve and Net Reclassification Index analyses showed better prediction by CAC volume than by Agatston, and the addition of CAC density to CAC volume further significantly improved prediction.

CONCLUSIONS: The inverse association between CAC density and incident CHD and CVD events is robust across strata of other CVD risk factors. Added to the ASCVD risk score, CAC volume and density provided the strongest prediction for CHD and CVD events, and the highest correct reclassification.

Copyright © 2017 American College of Cardiology Foundation. Published by Elsevier Inc. All rights reserved.

Karen Parrott
Guest

This is awesome, Dave, thanks for sharing. I had my CAC run via my docs order (zero calcium score btw) and I told the radiology dept tech I knew I needed a CIMT to look for soft plaque. That the CAC would only pick up hard plaque

Doc refused to order one, so I’ll be hitting up a CA licensed doc ( I can use my flexible spending card), or just find a place and pay out of pocket (easier) and getting a CIMT.

My latest Feldman attempt (3 days, high fat before my work insurance draw) didn’t give me lower numbers (or my hyper response was higher and it DID give me lower numbers- LOL). My work place changed parameters from LDL to HDL and my ratios are super great.

Thanks again for blazing the path and being a change agent in self testing. I look forward to data collection and hopefully a publication in the future. Onward and I’m cheering you every step.

sp salerno
Guest
sp salerno

Hi Dave,

Have you kept track of your fasting insulin/blood glucose/HOMA-IR since starting this?

Could be yet another example of its all about insulin…

regards,
Paul

Abhishek Anand
Guest
Abhishek Anand

Have you done a CT angiogram? My cardiologist said that unlike CAC, this test uses a dye and can detect soft plaques.
In young people, non-calcified plaque may be more prevalent:

Madaj, Paul M., Matthew J. Budoff, Dong Li, John A. Tayek, Ronald P. Karlsberg, and Harold L. Karpman. “Identification of Noncalcified Plaque in Young Persons with Diabetes.” Academic Radiology 19, no. 7 (July 2012): 889–93. https://doi.org/10.1016/j.acra.2012.03.013.

My calcium score was 0. Yet, I had a 99% blockage in my LAD. My symptoms (chest pain during exercise) appeared first last month, 5 months after being on LCHF.

Andy
Guest
Andy

Interesting to see how the right has a greater improvement to almost align with the left. Will be interesting to see what the next test reveals…

Abhishek Anand
Guest

Have you come across any study evaluating how well CIMT can predict the presence/severity of lesions observed using CT Angiogram?

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[…] referring to the Carotid Artery Updates which I’ve been doing every six months and how it was showing a regression. However, that […]