I would strongly encourage you to read through this blog and my own journey revealing the Inversion Pattern. Key moments were the Identical Diet experiment and the Extreme Cholesterol Drop experiment that I wrapped around the first presentation of my data for the Ketogains Seminar.
We had just returned from a nine week trip filming for the Cholesterol Code Documentary and we were gearing up to do more filming at Low Carb Denver. I had many great interviews lined up with very top level talent. But a few days later, in what I thought was an abundance of caution, I decided to cancel the trip in the very off chance I was an asymptomatic carrier for Covid-19 (coronavirus) given we just traveled the world, including many of “hot spots”.
Yet since getting back I had also had a series of discussions with many great doctors and researchers I’ve come to know through my research who were all very concerned about the seriousness of the outbreak coming from Covid-19. These are people I’ve never known to show such a level of distress, with some being somewhat apocalyptic in their predictions given the data on the ground.
After canceling the trip I did the same as I did for lipid research and went to see the numbers for myself. Just how fast are these cases increasing? What is the true mortality rate? How do all these metrics compare to influenza (flu)?
Within 24 hours I was convinced this was indeed very serious.
The Pandemic is Real
The virus, “SARS-CoV-2” that causes COVID-19 (“Coronavirus”) is indeed very contagious and compared to the flu, current data suggests it’s much more deadly. Just how contagious and how deadly is still being figured out, but we can safely say each metric is substantially high. Moreover, it appears to have a high rate of need for hospitalization with some requiring admission to the ICU (Intensive Care Unit) where many unfortunately have to be put on ventilators.
This tweet thread posted on March 6th went viral where it discussed the rate of spread being exponential:
Let’s conservatively assume that there are 2,000 current cases in the US today, March 6th. This is about 8x the number of confirmed (lab-diagnosed) cases. We know there is substantial under-Dx due to lack of test kits; I’ll address implications later of under-/over-estimate. 2/n
She goes on to explain if we are seeing an exponential increase where total cases are doubling every six days – then we would likely be looking at cases numbering in the millions by May:
We’re looking at about 1M US cases by the end of April, 2M by ~May 5, 4M by ~May 11, and so on. Exponentials are hard to grasp, but this is how they go. 4/n
I’m writing this on the morning of March 23, which is 17 days since her initial thread was posted. If confirmed US cases (lab-diagnosed) had been doubling every six days, they would be at 1,587 right now. Instead, they are at 35,070 (note this page continually updates).
This increase is likely due in part to expanded testing capability, not just the spread of the virus itself. That said, there’s little question as to the speed of viral spread within the US to have so many confirmed cases already.
My New Focus on Covid-19
While it has only been a couple weeks, I’ve certainly been pouring my time into trying to understand this pandemic. I’ve put up four different videos here, here, here, and here. I’ve also discussed this at length on both the 2 Keto Dudes and The Fat Emperor podcasts.
Personally, I’d much rather be focusing on lipids again. The days of comparing marginal P values seen in cardiovascular outcomes over decades seems so much more attractive than the exponential rates of change in mortality throughout the world over just a matter of weeks.
This crisis is extremely immediate, appears unusually deadly, and understandably commands all our attention. Much of social media interaction over this time has been to raise awareness, particularly regarding the need to “Flatten the Curve”.
1/ Please RT –> #FlattenTheCurve Hidden Costs Explained with Animation
At the time of my writing this we are seeing greater and greater quarantine efforts both around the world and within the US. This has led to many business shutting down, jobs lost, and lots of panic buying on necessities. Without question, there are extremely serious economic disruptions that will likewise have major consequences on many things we take for granted in the supply chain (many shortages of varying degree are likely ahead).
Naturally, this begs the question: Are we are doing too much?
On social media and in private I’ve been engaging many skeptics across the spectrum. Some are quite certain we won’t be posting the kinds of concerning rates we see right now in Italy. Sure, many ERs and ICUs will be maxed out, but they will be a fraction of the whole and we should just work better at resource allocation.
Others concede this is a particularly bad pandemic, but that it’s worth taking a more serious route toward herd immunity sooner given its inevitability anyway. Can we really all remain quarantined for months or even a year without wrecking our economy in lost productivity and setting us back years or even decades? Why not put extra focus on quarantining those at the highest risk and let others go about their business?
These are all very valid questions that should be explored and continually kept in mind.
As I write this I’m reading The Fed is sounding the word it will now have open-ended QE (Quantitative Easing), which in effect means it will create as much money (“money printing”) as it feels necessary to keep the economy going. This is very much a “trading tomorrow for today” effect as there will almost certainly be major economic consequences for this down the road.
Why Testing Matters
For me, just about everything comes down to the testing.
The sooner we expand our testing, the sooner we can plan more effectively for this disease and also get people back to work. Of course, “soon” is very relative here.
Without going into the different types of tests, let’s just put them into two general categories: those that detect the virus itself (typically via antigen) and those that detect immunity to the virus (typically via antibodies).
We are currently ramping up testing for the virus itself, but the demand still exceeds the supply considerably. Regardless, this doesn’t actually give us the kind of data we need to truly understand the rate of spread and existing communities given so many people are asymptomatic or choosing to self-quarantine in spite of mild symptoms (yet don’t know if they actually have it or not).
The game changer will be widespread “serologic tests” being rolled out soon (hopefully):
The serologic tests, which are different from the ones used to diagnose active infection, would allow researchers to test the blood of people who were not confirmed cases of Covid-19 in communities where the virus spread. They would be designed to look for signs that people have mounted an immune response after being exposed to the virus.
CDC Director Robert Redfield told Congress that the agency is working on two of these types of tests. “CDC has developed two serological tests that we’re evaluating right now so we can get an idea through surveillance what’s the extent of this outbreak, how many people really are infected,” he told a House panel. “That is being moved out now to do these extensive surveillance programs.”
It’s hard to put into words how important this milestone will be. It will allow us to gauge many important things simultaneously depending on the populations sampled:
What is a much more accurate proportion of infection?
What is a much more accurate reflection of hospitalization and Case Fatality Rate?
What is the likely rate of immunity turnover?
How close are we to herd immunity?
Again, these can only be applied one population at a time given the US isn’t one homogeneous territory. Moreover, there may be a higher priority to doing this surveillance testing in harder hit areas first.
Regardless — this has to be done soon. The sooner we have this capability, the better our decision making for next steps. South Korea is a rare success story through this pandemic in large part due to their extraordinary level of testing.
Coming Posts at Cholesterol Code on Covid-19
This site was never intended to cover a virus pandemic, of course. While it’s true we veer off topic at times, I don’t anticipate I’ll be putting a lot of material on here both for the content difference and, frankly, because the information is changing so rapidly anyway.
Hence, while I may do an occasional post such as this one in the coming weeks, most of my active updates on this topic will likely be on Twitter and my YouTube channel.
Final Thoughts
It’s worth repeating here what I have said elsewhere many times over – we’ll get through this.
Yes, this may indeed be a test of our generation like nothing we’ve ever experienced before. I truly believe we’re in for wave after wave of bad news. There will be many things we couldn’t have imagined before now that will become our reality in the coming months. We’re entering a dark time and we should own it.
With that said, we’ve never had so many incredible minds around the planet focusing on a single problem. They are all highly empowered with a level of communication and collaboration that never existed before now through information technology. And thus, we may see solutions ahead that will amaze us as they unfold.
I have a new saying that I’ll state again here. For all the numbers I obsess over, there’s none I’d want you to know more than the number 100. It’s the percent of times we as a species have made it through pandemics and whatever other great challenges we’ve faced. In time we regain our footing, respect our losses, and ultimately improve to a new quality of life than what we had before.
We’re now wrapping up our international trip and will be heading back to “the states” this week. We’ve traveled 17 countries and 28 cities for the duration via plane, train, automobile, ship, and just about every public transit you can imagine.
Over Fifty Hours of Interviews… So Far
In all, we gathered 36 interviews with well over 50 hours of footage! But more than that, we met people face-to-face where they live. Let me tell you, it really makes a difference.
Special thanks to the 36 we’ve interviewed so far, including doctors Aseem Malhotra, Bret Scher, Caron Sak, Ken Sikaris, Nadir Ali, Oliver Smith, Paul Mason, Richard Cheng, Victoria Buntine, Zoe Harcombe. (And of course, a special thanks to my fellow engineer, Ivor Cummins for some additional flavor in his interview!). In all, we traveled to 17 countries and 28 cities over two months.
Aseem Malhotra
If you ever want people to feel right at home when you interview them, meet them there. If you want to know a doctor’s bedside manner, set up your chat in their office. No amount of broadband internet webcam conferencing can replace that level of connection you get in person at the one place they feel most like themselves, and it really comes through in the footage.
Between the outline work and existing content we were picking up, it became clear this was getting much too big to be a single feature length documentary, so we really opened up to the possibility of making it a series.
Zoe Harcombe
Shifting Focus to Low Carb Denver
This week we return to “the states” and will soon after be coming to Low Carb Denver where we will be gathering additional interviews with many at the conference. For details and signup, please see our updated Documentary page.
As with the international trip, we hope to gather many medical experts with opinions or research on the topic of cholesterol, heart disease, and/or the phenomenon of high LDL for some who go on a low carb diet.
My primary costs are the many frequent and expensive blood tests I take for this research and data. Any size donation is appreciated. Thank you for your support!
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