I would strongly encourage you to read through this blog and my own journey revealing the Inversion Pattern. Key moments were the Identical Diet experiment and the Extreme Cholesterol Drop experiment that I wrapped around the first presentation of my data for the Ketogains Seminar.
As CholesterolCode continues to grow, our ability to handle all the comments coming in has been a concern, but we didn’t want to miss the opportunity to answer the awesome questions you guys have either. Luckily, not too long ago, Low Carb San Diego happened…
Introducing Debbie
At Low Carb San Diego, I met Debbie – she used to be an engineer in silicon valley for 33 years, but is currently retired. She also happened to mention that she was interested in helping out Dave and I, and had the time to offer. She is passionate about learning as much as possible, and helping to get people accurate information so they can make informed decisions, and I felt that this attitude was a good fit, and her help might be a possible solution to our dilemma.
A Warm Welcome
If you haven’t guessed already, all of this is leading to introducing Debbie to the CholesterolCode readerbase! Debbie will be helping out by answering some of the comments that come in starting this week. I’ll still be replying to many of the comments that come in, as per usual, but don’t be surprised if you see Debbie around as well. This will hopefully mean, over time, even faster responses to comments especially during conferences as we continue to grow.
Note from producer: In the efficacy and safety statement for the trial mentioned it lists Merck Sharp & Dohme (manufacturers of simvastatin) as well as Hoffmann-La Roche (manufacturers of the vitamins used) as providing partial funding for the study:
The study is being funded by the UK Medical Research Council, the British Heart Foundation, Merck Sharp & Dohme (manufacturers of simvastatin[…]) and Hoffmann-La Roche (manufacturers of the vitamins[…])
However in the published paper of the results it states the following:
The Clinical Trial Service Unit has a staff policy of not accepting honoraria or other payments from the pharmaceutical industry, except for the reimbursement of costs to participate in scientific meetings.
44:56 If there were a trial that showed that people with
high HDL, high LDL, and low triglycerides didn’t benefit from statins would
[Ethan] want to know that information?
52:40 Open data, machine learning, and possibilities moving
forward
56:20 Non-HDL and mortality from the NHANES dataset
Twitter exchange mentioned:
1/ So here's some "realtime science" for you… @ethanjweiss pinged me in another thread regarding non-HDL regarding risk here: https://t.co/brFpCiXDpa I realized I hadn't actually checked out non-HDL in NHANES to this point. The raw results are pretty interesting…
58:30 Changes in ability to connect with researchers and
scientists
1:00:05 What does Dave mean by risk?
1:04:10 Modifications to low carb to achieve lower LDL
1:08:55 What Dave has learned about the importance of
rigorousness in self-experimentation
1:13:29 Can self-experiments have benefits applicable to
people beyond the person doing them?
1:17:29 Cholesterol biosynthesis
1:18:40 Reverse causality – is there a possibility that the
lipoproteins are reflecting a problem and not causing it?
Note from producer: I attempted a follow-up to see if
I could find any studies looking at the impact of infusion of native mouse
lipoproteins on atherosclerosis development, but I have not found any thus far.
1:24:33 Clotting, vascular injury, and engineering
We’re doing a #BloodTestingDrive at Low Carb Houston where people can have their labs taken right there at the conference. Appointments will span the mornings of Thursday and Friday, and as always, we recommend being 12-14 hours fasted before the blood draw.
Nadir and I discuss the blood testing on location, how it works, what tests are taken (listed below) and next steps:
All Tests:
Nuclear Magnetic Resonance (NMR), also known as a LipoProfile – includes both standard cholesterol markers and a subfraction analysis (such as lipoprotein counts “LDL-P” and “small LDL-P”)
This month we have a lot going on that will limit our participation with the site.
I’m (hopefully) in the last stages of the book and looking to lock the manuscript soon. I told my publisher that I’d be very head down through August to make it happen.
Siobhan is off this week, and once returning will be helping us with the launch of a new project.
But never fear, we have some great material for you to check out in the mean time.
AdapNation Article
I just had an interview with AdapNation on lipids (likely to be released next week). But they had first came on to my radar a little earlier with this very extensive article they wrote on cholesterol. It’s actually very visual and layperson-friendly, so I thought I’d given them a shoutout.
Nathan Owens is on a Research Tear
As always, we’re interested in lipoproteins and their participation in the immune response (if you haven’t already read the amazing piece on this from Siobhan Huggins, do so right now!). I’ve been impressed with many new studies and ideas Nathan has been discussing lately with this topic on social media. Here’s one thread worth reading through:
Lipoproteins are part of the immune system. All drugs I’ve looked at so far (Statin, CETPi, PCSK9i, Niacin) have pleiotropic effects that modulate the immune response to endotoxins, or change the function of Lipoproteins in clearing endotoxins. @siobhan_huggins@DaveKeto
Riveting Interview with Biochemist Patrick Theut on CAC
This question comes up a lot – can CAC be reversed? My answer has continued to be “I don’t know.” But perhaps the most incredible story I’ve seen to date comes from this episode of Ivor Cummins interviewing Patrick Theut on his own journey with this very question.
My primary costs are the many frequent and expensive blood tests I take for this research and data. Any size donation is appreciated. Thank you for your support!
Recent Comments