Mar 28

Watch This Video

General topics covered:

  • I explain my cholesterol increased after going low carb and then drove me to learn everything I could about it
  • The lipid system appears to be extremely similar to a software network in many ways
  • I record everything I ingest and take a myriad of blood tests in a series of constant N=1 experiments
  • The Inversion Pattern and how the previous three days of diet impact cholesterol test results significantly, and in the reverse (see graphic below)
  • The Identical Diet experiment where my sister and I ate exactly the same food for 13 days with extremely close correlations
  • The Extreme Drop experiment where I manipulated my cholesterol numbers with diet around the first presentation of my research
  • Shared the data of many others who have likewise done the protocol to prove the Inversion Pattern


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28 Comments on "Watch This Video"

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Some of this we have known from back in the 1960s – the effect of carbs on trygly. – History_of_Fructose_Carbs_and_weight-loss The most important point is one from the questions – is higher cholesterol a cause or symptom of the injury of arteries? Cholesterol recruitment is part of normal wound healing. What if they have the arrow of causation backwards? What is missing is FFA – (might be good to keep this low). I don’t think we evolved LDL to cause heart disease. As is true of most proteins – they rarely have a single role. One role often overlooked is… Read more »
The only way I know of to change the pattern of small dense vs light fluffy LDL to the better is to reduce carbohydrates – thus I’ve thought of the expensive tests as an over priced glucose test. I am thinking that the current assumption that LDL is causative of CAD if false. It could easily be a side effect of higher BG – a confounding variable. The narrative I think is most likely true is that the initial damage – the thickening of the inner intima is due to a growth factor – possibly insulin. It could be that… Read more »
Jae Chon
Dave, I have been on the ketogenic diet for 3 weeks now and have lost 10 pounds. I made this lifestyle change because I have been on medication for 1.5 years now to treat my type 2 diabetes and high cholesterol. Like everyone else, the last 3 weeks have been amazing and I have seen all the benefits being on keto. When I started keto 3 weeks ago, I immediately stopped taking all my medication for type 2 diabetes because I do measure my glucose many times throughout the day and if my sugar level spikes, I can go back… Read more »
Hyper-Responder Neville
Hyper-Responder Neville
Hi Dave, Firstly, great presentation, and thanks for taking the effort to get this out there. Just curious to get your thoughts on a few things.. – What are your thoughts on using a very very low dose statin? For example, i’ve tried using 5 mg crestor every other day and it keeps my LDLp in control! – In this video [https://youtu.be/K41m5_RXR-k?t=5m32s] Dr Bernstien mentioned that the radiation is not in-significant. Again, not clear if he’s talking about calcium score or coronary CT angiography. Are you aware of the radiation involved in Calcium Scores? I’m curious because getting a calcium… Read more »
Hyper-Responder Neville
Hyper-Responder Neville
Hi Dave, Just went through your comments on the other post. I think you have answered the statin questions there. Should’ve looked at them before asking, my bad! I do know that in my case (and where my numbers are) i don’t think i can take an LDLp of > 3500 lightly. If i do an LCHF, i probably will decide to be on a statin + zetia. I’m also in process of trying a plant based diet out. Transition from a LCHF to carb diet is not easy. Low blood sugar symtoms, feeling sleepy after meals, etc had become… Read more »
Eric Bozinny
Hi Dave – At first, I didn’t think I’d learn much from your video, but damn was I wrong! The inversion patterns are crazy correlated. A question – in your talk, and on your site, I didn’t find a clear hypothesis for your enlightening experiments. The one that jumps to mind (but not sure if you would agree), is that if LDL and LDL-p counts change so dramatically with just a 3 or 5 day modification of diet (or more pointedly, the number of calories consumed HFLC), then how can cholesterol be used as a marker for CVD by public… Read more »
Chris Warrenton
Hi Dave– I have a story similar to Jill’s! My TC has been high (>230) ever since I started testing back in my 30’s (I just turned 57). My HDL has always been high as well though, typically over 80. I’ve been on keto for 2+ years and started for the same reason you did, pre-diabetes. I had my cholesterol checked a couple weeks ago and my doctor’s PA immediately yelled STATINS at me (non-fasting, TC 283, LDL 170, HDL 87, Tri 92, VLDL 18), which I refuse to do given the increased risk of statin-induced diabetes in post-menopausal women.… Read more »
Sarit Shamai

I’m 53 and I’m in ketogenic diet about 1.5 years.

I made the 3 days high fat:
day1: 3685 kcal, protein:147gr, fat: 326 gr, carbohydrate: 30 gr, fibers: 7 gr, net carbohydrate: 23gr
day2: 3680 kcal: protein: 100gr, fat 350 gr, carbohydrate: 33 gr, fibers: 12 gr, net carbohydrate: 21gr
day3: 4748 kcal: protein: 100gr, fat 468 gr, carbohydrate: 30 gr, fibers: 7 gr, net carbohydrate: 23gr

TC decrease from 390 to 371
LDL decrease from 283 to 260
TG increase from 194 to 231
HDL decrease from 68 to 64

so, from my point of view. the change is minimal and the increase in TG was problematic.



Thanks for the data!

Obviously, the protocol isn’t mean to change your steady-state lipid levels (its tough to eat so much!). It’s really meant to show how dynamic they are, and in what direction they move in response to food. It can also be useful when dealing with someone who incorrectly believes they are static, who might say, give you a different insurance rate.

I agree TG is a bit high. Has that changed compared to pre-keto?


Sarit Shamai

thanks for your answer.
I know it’s not a way of life but I hope the change be greater.
my number before the ketogenic diet;
cholesterol: 250
TG; 207
HDL: 34-40
LDL; 174

there is no doubt that the change is because of the diet.


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