Jan 03

The Capstone Experiment – it’s time to #rethinkLDL

As of today, I’m declaring Phase I and II of my research complete.

  • Phase I spans December 2015 to May 2017 where I was focused primarily on the Inversion Pattern.
  • Phase II spans May 2017 to January 2018 where I was focused on Energy Status.

The Capstone Experiment combines both legs of this theory and demonstrates how fluid and agile cholesterol markers are when modifying dietary sources of energy in real time.

Naturally, there are many questions still to answer given how much there is to unpack. But for now, I want to put a white-hot spotlight on the most central and unmistakable observation of this experiment:

Cholesterol is a passenger, not a driver. Its markers are extremely agile and highly influenced by the larger energy metabolism. This runs counter to medical mainstream opinion.

Next Steps

  • Certainly, I’d like to put this into a formal study. But the process of organizing these and raising money tends to be slow, which is why I haven’t taken a lot of time pursuing it to this point. I’m an engineer, not an academic, so I’d prefer to find someone who can better navigate those waters to make this happen.
  • Falsify this! If you’re reading this and you have alternate theories or a way I can disprove this working theory, please let me know. I can’t emphasize enough that I appreciate contrarian views, so long as they are materially relevant and productive.
  • Lastly, I’ll be taking a bit more personal time in the next week to rest and catch up some time with family. Everyone has been very patient and understanding of my work through this point, chief among them being my wife. These experiments take a lot out of me, with this one being the most intensive one yet.

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14 Comments on "The Capstone Experiment – it’s time to #rethinkLDL"

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Hi Dave, First of all, thank you for your work. It is absolutely amazing and it cant be appreciated enough. But one think appears to me to not make sense: Why is higher LDL associated with a longer life? (David Diamond) First some thoughts on why it shouldnt happen: -high VLDL due to high DNL. Basically the metabolic syndrom typ. This clearly wont make one live longer, rather the opposite. -the closer someone is to death, the less appetite this person has, the less he eats, the higher his LDL will be (classical inversion pattern). But again the lower appetite… Read more »

Oh WOW, i did not think of that. Thank you !!

In this context, how trustworthy is a standard lipid panel in terms or LDL in your opinion? Does the Friedewald-Formula provide a clue if TG are not to high (<150) or would you always test them directly?


really interesting Dave,

Do i get it right: stress, LPS, toxicity, injuries etc lower LDL and TC when it occurs acute and short term (used up by body); whereas increase LDL and TC when they are chronic (upregulation by body), right?

concerning the VLDL: so ramped up DNL, producing lots of VLDL doesnt (necessarily?) increase LDL?


How can you make your conclusions based on only 2 or 3 data points per phase?

Heather Varaleau
Dear Dave Feldman, I’m trying to gather information on the risks (if any) of very low LDL. I am part of a vegan-keto facebook group on which a few participants have reported very low LDL numbers (in the 40-50 range). Their doctors are encouraging and supportive of these very Low LDL numbers, and I am concerned that there are health consequences to such low LDL. I have tried to find reliable information on the impacts of very low LDL, but have found little. I have read this article (http://onlinelibrary.wiley.com/doi/10.1111/joim.12614/abstract) which generally concluded little to no risk, but is sponsored by… Read more »

Dave, are you still satisfied with that Cardiocheck (PTS diagnostics) device? Do you have any other thoughts about it? (Your experiments showed that it is reasonably accurate). Do you know any better similarly priced items in the market? I want to buy one. On the lab test days, approximately, how close to the lab blood draw were the measurements by Cardiocheck? Thanks.