Jul 23

Ketofest Cholesterol Presentation Blowout

Yesterday was an amazing experience!

It was the second Ketofest held by the 2 Ketodudes in New London, CT. And as with the first year, the last day was reserved for “Science Sunday”. On deck were many speakers including yours truly. But never mind my presentation, I want to tell you about three others that cumulatively made my year…

The Paradox of Insulin Resistance versus LDL Cholesterol – Dr. Nadir Ali

Nadir had an extremely fascinating discussion on LDL cholesterol, insulin resistance, longevity, and even the problems with how industry conducts the science on how we study heart disease.

He had a number of graphs, flow charts, and illustrations that brought through the message impressively. He even covered lesser known protective aspects of LDL such as disrupting quorum sensing used by bacteria.

Your Marvelous Mevalonate Machine vs the Statin Slayer – Nick Mailer

I don’t even know where to begin with this spectacular presentation. Nick took us on an animated journey though biochemistry like nothing I’d ever experienced before. He painstakingly animated nearly every slide so we could observe the processes he was describing in deep detail as though it were happening in front of our eyes.

While it was delightful to see his naming me as one of his inspirations for taking his presentation in this direction, I can assure you he certainly took this to the next level. If you like my use of animations for presentations, imagine this increase by an order of magnitude… and for the record, I’m being quite literal here!

LDL: Primed to Protect (Cholesterol’s role in defense and repair) – Siobhan Huggins

I saved Siobhan’s speech for last as I can’t even begin to describe impressive it was. She has been working tirelessly on it for quite a while, and the effort truly shows. She managed to strike the perfect balance between dense content and friendly, accessible illustration.

She discussed her personal journey into the research, the many roles of LDL, Lp(a), and the lipid system as a whole. Moreover, she elucidated the common misconception of inflammation and how it should be understood for the process of repair rather than the problem it’s addressing in the first place. And perhaps most important of all, she wraps it up with a discussion on the importance of not taking any marker in isolation and to see the system as a whole.

It’s worth pointing out this was Siobhan’s first presentation in front of a live audience and as many of us agreed, she knocked it out of the park. 😀

A Truly Good Day

As I remarked several times yesterday, I felt genuinely ecstatic for how powerful the messages came across from everyone above on the subject of lipids and cholesterol in particular. I’m not sure when all these videos will be available on YouTube, but we’ll certainly have a post up when they are — and I’d certainly give each of them my highest recommendation.

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22 Comments on "Ketofest Cholesterol Presentation Blowout"

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Eric Rodgers

Will talks be available online? Either pay or free?

Siobhan Huggins

Yes, they’ll be available for free on youtube after a bit (not sure exactly when) 🙂

Nick Mailer

They will soon be available on YouTube for free.


I believe at least some of them will be online, but not for a while. Or at least that’s what the 2 keto dudes inferred in one of their podcasts. I think they wanted to entice people to go to Ketofest, instead of waiting.

I really wanted to go (was there last year), but Ketofest happened the same exact weekend as a retreat our family went on. Hopefully these won’t be scheduled at the same time next year.

Nick Mailer

Thanks Dave. You really inspired me to do this. I spoke to Professor Feinman on the trainride back, and he commented on how crazy it was that chemistry was still being taught as it had been to him, not taking account of new technology and heuristic advances. I’d love if my presentation sparks a new set of similar presentations for every metabolic pathway! If it doesn’t, I guess I’ll have to do it myself 🙂


I watched your presentation via the streaming during the event. If my chemistry teacher had been half as effective delivering information as you were, I would be a retired chemist now. instead of IT professional. I hope you continue to spread your knowledge via ketofests, ketocons, etc.


AWESOME! Congratulations to Siobhan on her success! I assume more on that will be coming and I look forward to it. I’m also *hoping* the 2 Ketodudes will include some of the talks on their podcasts.

Siobhan Huggins

The talks may be discussed in passing on the podcast, but even if not they’ll be available to the public on youtube after a while 🙂

And yes more in the works as always.

Nick Mailer

My talk – and to a degree Siobhan’s talk – will be impossible to render via audio podcast, as they rely profoundly on visuals

Steven Horvitz, D.O.

Darn it. I should have been there!!

Judi Window

I couldn’t make Ketofest this year but can not wait to see these presentations! I’m 2+ years Keto and all my blood markers are great with the exception of extremely high LDL, ApoB, and slight inflammation. Now I am on a quest to figure out why. Thank you for your work and this post.


Hey thanks for all the great info. I stumbled upon this page after doing some searching. I have been on a keto diet for about 9 months, I have lost almost 40 pounds but just got some blood work and compared it to what it was at this time last year and got scared because my LDL jumped up so high.

Sep of 2017- HDL-50, LDL-149, Triglyceride-83, Total Chol-216

Aug of 2018- HDL-58, LDL-192, Triglyceride-57, Total Chol-261

Reading through here it seems like this isnt uncommon, so that is good.





Great presentations at Ketofest 2018. I thought everyone was great and I have watched them over several times . You were all great . I ran into this article and was wondering if anyone has some more thoughts about the ideas of the article by Vladimir M.Subbotin “Excessive intimal hyperplasia in human coronary arteries before intimal lipid depositions is the initiation of coronary atherosclerosis and constitutes a therapeutic target” Theories like this could go a long way to explain what we see in Dave’s experiments and the discord with modern diet heart hypothesis , any thoughts ?


Whaaaaat?? Do intermittent fasting raise apoB levels? Am I confused … Fasting is not healthy? I thought that by improving the TG / HDL index by fasting, the amount of apoA was also increased and that of apoB was reduced…

Siobhan Huggins
During longer fasting periods (>14 hours) LDL and apoB go up because they are helping to supply energy to your cells. However, over the longer term (if tested while fasted 12-14 hours) those who do intermittent fasting can see their apoB and LDL go down over the longer term – if it was high due to a poor environment. It’s worth noting that there are various situations where apoB can be high – some due to injury or infection (bad over long term), some due to fat-based energy demands (jury is out on whether this is truly “bad” or not,… Read more »

I went straight carnivore diet for 3 weeks and these are the numbers. I’m a very active male 30 yrs old weight training and grappling 6 days a week. APOE 3/4 genotype. These numbers are scary to look at considering I was at around 200 total cholesterol doing a Paleo style balanced diet . Keto I was in the high 260’s range and now this is carnivore:

Total Cholesterol 407
LDL: 281
HDL: 110
Triglycerides: 53
LDL particle number: 2543
LDL small: 188
LDL medium: 354
HDL large: 11960
LDL Pattern A: 229.9

Siobhan Huggins

I would expect LDL and total to be higher on a fat centric diet. It looks like you’re a lean mass hyper-responder.

LDL particles transport fat-based energy to cells after all, so a higher demand for fat-based energy (due to diet) can yield a higher number.