Jul 17

Ketofest Cholesterol Experiment – Preliminary Results

While there is still more analysis to collect and unpack, here are the preliminary results from the Ketofest Cholesterol Experiment.

Did it meet the hypothesis? You be the judge:

I can’t possibly express enough appreciation for PTS Diagnostics, the great 2 Keto Dudes and the truly generous volunteers who took this journey through the experiment with me. Thank you so much for your participation!

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26 Comments on "Ketofest Cholesterol Experiment – Preliminary Results"

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Shashikant Iyengar

Thank you for sharing the data
Lots of learing from your studies


Is there statistical significance??


The p-value is .01426. The result is significant at p < .05.


Did the folks in the test group track their macros and will that data be available too?


More than macros, the test group did 100% photo logging of all their food and drink over the 6 days! I’m looking forward to Dave’s analysis of this data.


Congratulations on this incredible experiment. Well done everyone! Really excited to see what the future holds for our understanding of cholesterol.


Is there data to show why a few people didn’t go down? Does obesity play a role? Thanks.


What about eating windows?
Time restricted feeding seems do able and gets results quick!
Eating once a day keto

Hi Dave. Further thoughts on your results. I think there are two things that can explain what you are seeing. 1. Metabolic channeling. 2. The Randle Cycle. There are a number of questions that come up in looking at your results, ie: 1. Why do hyperresponders exist. 2. What explains your lipoprotein dynamics. First your “Feldman Protocol”. Metabolic channeling is a real phenomenon and indicates it may be useful to think of two pools of LDL, pool a consisting primarily of LDL I/II gestated through, primarily, VLDL2 and pool b consisting primarily of LDL III/IV/V gestated through, primarily, VLDL1. Pool… Read more »
Are you collecting genetic markers from ppl also ? It occurs to me that most biohackers will have their dna and it might be more than just apoe that might explain variances. I’m apoe3/4 like you but I also have the butylcholinestrinase K variant rs1803274(A;G) ( assn with high ldl) rs2075650(A;G) (ldl-chol / alz) cyp3a5 non expressors (aka gs 155) rs2075650(A;G) 2 2x higher Alzheimer’s risk rs4420638(A;G) 2 ~3x increased Alzheimer’s risk; 1.4x increased heart disease risk ; increased LDL rs17228212(C;T) 1.26x increased risk for heart disease rs1260326(T;T) slightly higher risk for gout rs4939883(C;T) associated with higher HDL cholesterol rs3843763(C;T)… Read more »
Richard Fish

Thanks Dave. Great information. I am a recovered T2D through ketogenic diet and intermittent fasting. Had an unexpected high LDL-c an my last check and Doc recommended a station. I demanded a CAC test – and refused the statin with A1C of 5.1 and CAC score of 0!

I made a mistake on the last blood draw. I fasted for three days immediately prior to giving the sample! After reviewing your results I will eat LCHF prior to the next test. Want to bet on the over-under on the next LDL-C?


Kudos for being such a strong advocate for your health, and congrats on the CAC 0 and great A1C!

As a basis for the over-under guess, what was your 3-day fast LDL-C from last time? (And TC, TG, HDL-C, for context)


[…] Of course, the preliminary results of the Ketofest Cholesterol Experiment are now posted. […]


was weight track during the experiment ? any weight loss even it is insignificant ?

maybe a dxa scan could be included in the data ?


[…] fact, Mr. Feldman is working with Head Up Health for tracking his own labs and for many others taking part in his […]


[…] far with my Lipids. Despite an additional 200g/day of fat, my LDL was effectively unchanged in the Ketofest experiment. I knew exercise was potentially a confounder given Dave’s experiments with distance running, but […]