Oct 31

Infographic of Prediction Experiment

For more details on this graphic and the story behind it, see the post following.



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  1. Diego Espinosa

    Hi David,
    Remarkable, but in many ways not surprising. We need lots more biohacking experiments like yours — millions, actually! My start-up, Healthcoin, is seeking to document them on a blockchain. The idea is we can use that “certified proof” of prevention to channel recognition and rewards to those that are proving prevention right. We want to create a vast, “Living Chain” of proof, one that scales across the globe and over lifetimes, and can be accessed by medical researchers.

    If interested, I’d like to include you in an early pilot of the technology. Please email me for more details.


    1. Dave

      I applaud your endeavor! Obviously I’m a big fan of advancing our data as much in the aggregate as possible.

      At the moment, I’m a bit hammered between business and the current experiment I’m on. But if things loosen up more in the coming months, I’ll definitely reach out. 🙂

  2. Annlee

    Reminds me of Dr. Atkins – when weight loss stalled, he’d advise a “fat fast.” Jackie Eberstein has commented on it.

    1. Dave

      Very true. You might be interested in what happened with my weight over this period, which will be outlined in coming Part II.

  3. Pam Forrester

    Hi Dave,
    I just found your site. I am a hyper responder. I have been LCHF for 6 years. I hate to go to the doctor who wants to put me on a statin, which I will not do. But why does this happen? Can you point me to the link where I am sure you explained it. Also loved loved loved the illustrated Simple Guide to Cholesterol. Is part III up yet?

    1. Dave

      As to why some of us are and some aren’t hyper-responders, I don’t yet know. In my case I have an especially interesting situation where both my dad and sister are on the diet but I’m the only one of us who saw a dramatic increase in my lipids (they both saw a very marginal increase). This opens to the door to it being behavioral or circumstantial. But thus far I don’t have a lot more than that. There appears to be a slightly higher proportion with ApoE4 carriers and a slightly higher proportion with lean and/or athletic over heavier/sedentary — but each of these are still pretty loose.

  4. Patrick Fannin

    Dave, I am 48 and have been on a ketogenic diet for about 5 years. I recently had a coronary CT scan that my doctor wanted me to do because of high cholesterol and because of my diet. My calcium score was in the 70th worst percentile for for calcium deposits. I am wanting to consult with someone in the keto community who can help me understand why I have high levels of calcium deposits and what to do about it. I don’t want to go back to my pre-keto life but this test result has scared me. Thanks for any guidance or referral.

    1. Dave

      Hi Patrick-

      Sorry to hear about your CAC score. One of the unfortunate difficulties of getting it now is the inability to determine how much of the score attributes to the lifestyle before the diet vs the lifestyle during. I’ve talked with many in the low carb community who (like you and I) have very high cholesterol but have maintained low or 0 CAC scores in spite of this. But this is anecdotal and to my knowledge there isn’t a sizable study with regard to CAC sampling with a LCHF diet.

      I myself have a 0 CAC (from Feb 2016, 1 year into keto) and just got another this last Tuesday of 0 as well. But I considered the first one a baseline and will likewise want to see it again five to seven years later.

      Ivor Cummins of thefatemperor.com has many great articles and presentations on the CAC test and risk assessments. One key point you’ll be interested in is that your standing score doesn’t matter as much as its *progression*.

      I’ll reach out to you offline with some doctor recommendations.

    2. GCGeo

      What is your LDLp? My personal experience has been that high LDLp drives the process that eventually shows up as CAC score > 0. Keep in mind that CAC shows up late in the game so even with a score of zero you could still be subject to a long term ongoing disease process that may not manifest for yet many years. Check out Davis’ book “Track Your Plaque.” It was written some years ago but still has a wealth of useful information. At the time the book was written, Davis counseled low saturated fat along with his no wheat and low carb recommendations. I wonder what his take on saturated fat is today. Good luck. Keep us posted on your situation.

  5. Dwight

    Hello Dave

    Your data is interesting though scary. Your calories per day (high days) are too high. Your cholesterol numbers freak me out.

    You appear to be a “youngish” man meaning that because your coronary arteries start with a wide diameter they are closing. You can’t tell because of starting diameter. I’m betting the smaller coronary arteries are closing. Penis and peripheral arteries.

    If you continue to be low carb obsessed My suggestion is to Check degree of closure of coronary arteries by non invasive means like PET and so on. You might be one of the lucky folk who are not fat sensitive. Robert Atkins said about 1/3 of people (I think) have to be careful about fat intake.

    A major problem with large fat intake i.e. High calories from fat is that you are not getting the phytonutrients necessary. Towards the end of Atkins life he was asked what he would do differently if any. He said he’d eat a lot more greens. Fat has a very low nutrient density.

    With respect you seem to be missing the forest for the trees.

    1. Dave

      Hi Dwight-

      – Yes, I’m tracking both blood indicators for atherosclerosis and having many ultrasounds (CIMT) and scans. In fact I just got back from NY where I completed one of the most advanced ct heart scans in the world, the 640 slice.

      – Not sure about the “necessary” phytonutrients you’re speaking of. I do eat broccoli, salads, spinach, etc — but the most nutrient dense food I eat is liver, which I’m actually trying to eat more of as well.

      – Not all fats are the same nutrient profile, many are nutrient poor. But this is likewise true for greens as well.

      Interesting comments, Dwight. 🙂

  6. Eric Rodgers


    Interesting comments do you have any links to Atkins comments where he said he’d eat a lot more greens?



  7. Miguel

    Hello Dave,

    What you are doing is amazing! Thank you for your work! I am interested in your food log for the higher calorie days. I see your macros percentages but what foods did you intake to achieve such a higher saturated fat and protein? I would like to follow your experiment myself and I currently use Cronometer to track my foods. Thanks!

    1. Dave

      I ate a lot of cheese, eggs, heavy cream, AdaptMeal, burgers, Nathan’s skinless hotdogs, peanut butter and my low carb pizza to name a few.

      Try to fashion something you yourself would like to eat but still meets those macros. And try to do it with real food as much as possible. (i.e. don’t get the vast majority from, say, bulletproof coffee)

      1. Miguel

        Thanks! And, avoid coconut and MCT oil but what about Brain Octane Oil, coconut milk or cream? Would these effect lipid results?

        1. Miguel

          And is Extra Virgin Olive Oil ok?

  8. Jorge Estevao

    Monosaturate fats and fish oil are known to increase HDL and decrease LDL. Have you tried to increase these instate of satured fat on your diet and watch the results?

    1. Dave

      I did an 11-day experiment where I upped my MUFAs and reduced my SFAs early last year, but didn’t see a substantial change. That said, I’d like to do another that would be much more tightly controlled and this time I’d have the benefit of the CardioChek for more frequent testing as well.

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