Oct 31

Infographic of Prediction Experiment

For more details on this graphic and the story behind it, see the post following.



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  1. Diego Espinosa

    Hi David,
    Remarkable, but in many ways not surprising. We need lots more biohacking experiments like yours — millions, actually! My start-up, Healthcoin, is seeking to document them on a blockchain. The idea is we can use that “certified proof” of prevention to channel recognition and rewards to those that are proving prevention right. We want to create a vast, “Living Chain” of proof, one that scales across the globe and over lifetimes, and can be accessed by medical researchers.

    If interested, I’d like to include you in an early pilot of the technology. Please email me for more details.


    1. Dave

      I applaud your endeavor! Obviously I’m a big fan of advancing our data as much in the aggregate as possible.

      At the moment, I’m a bit hammered between business and the current experiment I’m on. But if things loosen up more in the coming months, I’ll definitely reach out. 🙂

  2. Annlee

    Reminds me of Dr. Atkins – when weight loss stalled, he’d advise a “fat fast.” Jackie Eberstein has commented on it.

    1. Dave

      Very true. You might be interested in what happened with my weight over this period, which will be outlined in coming Part II.

  3. Pam Forrester

    Hi Dave,
    I just found your site. I am a hyper responder. I have been LCHF for 6 years. I hate to go to the doctor who wants to put me on a statin, which I will not do. But why does this happen? Can you point me to the link where I am sure you explained it. Also loved loved loved the illustrated Simple Guide to Cholesterol. Is part III up yet?

    1. Dave

      As to why some of us are and some aren’t hyper-responders, I don’t yet know. In my case I have an especially interesting situation where both my dad and sister are on the diet but I’m the only one of us who saw a dramatic increase in my lipids (they both saw a very marginal increase). This opens to the door to it being behavioral or circumstantial. But thus far I don’t have a lot more than that. There appears to be a slightly higher proportion with ApoE4 carriers and a slightly higher proportion with lean and/or athletic over heavier/sedentary — but each of these are still pretty loose.

  4. Patrick Fannin

    Dave, I am 48 and have been on a ketogenic diet for about 5 years. I recently had a coronary CT scan that my doctor wanted me to do because of high cholesterol and because of my diet. My calcium score was in the 70th worst percentile for for calcium deposits. I am wanting to consult with someone in the keto community who can help me understand why I have high levels of calcium deposits and what to do about it. I don’t want to go back to my pre-keto life but this test result has scared me. Thanks for any guidance or referral.

    1. Dave

      Hi Patrick-

      Sorry to hear about your CAC score. One of the unfortunate difficulties of getting it now is the inability to determine how much of the score attributes to the lifestyle before the diet vs the lifestyle during. I’ve talked with many in the low carb community who (like you and I) have very high cholesterol but have maintained low or 0 CAC scores in spite of this. But this is anecdotal and to my knowledge there isn’t a sizable study with regard to CAC sampling with a LCHF diet.

      I myself have a 0 CAC (from Feb 2016, 1 year into keto) and just got another this last Tuesday of 0 as well. But I considered the first one a baseline and will likewise want to see it again five to seven years later.

      Ivor Cummins of thefatemperor.com has many great articles and presentations on the CAC test and risk assessments. One key point you’ll be interested in is that your standing score doesn’t matter as much as its *progression*.

      I’ll reach out to you offline with some doctor recommendations.

    2. GCGeo

      What is your LDLp? My personal experience has been that high LDLp drives the process that eventually shows up as CAC score > 0. Keep in mind that CAC shows up late in the game so even with a score of zero you could still be subject to a long term ongoing disease process that may not manifest for yet many years. Check out Davis’ book “Track Your Plaque.” It was written some years ago but still has a wealth of useful information. At the time the book was written, Davis counseled low saturated fat along with his no wheat and low carb recommendations. I wonder what his take on saturated fat is today. Good luck. Keep us posted on your situation.

  5. Dwight

    Hello Dave

    Your data is interesting though scary. Your calories per day (high days) are too high. Your cholesterol numbers freak me out.

    You appear to be a “youngish” man meaning that because your coronary arteries start with a wide diameter they are closing. You can’t tell because of starting diameter. I’m betting the smaller coronary arteries are closing. Penis and peripheral arteries.

    If you continue to be low carb obsessed My suggestion is to Check degree of closure of coronary arteries by non invasive means like PET and so on. You might be one of the lucky folk who are not fat sensitive. Robert Atkins said about 1/3 of people (I think) have to be careful about fat intake.

    A major problem with large fat intake i.e. High calories from fat is that you are not getting the phytonutrients necessary. Towards the end of Atkins life he was asked what he would do differently if any. He said he’d eat a lot more greens. Fat has a very low nutrient density.

    With respect you seem to be missing the forest for the trees.

    1. Dave

      Hi Dwight-

      – Yes, I’m tracking both blood indicators for atherosclerosis and having many ultrasounds (CIMT) and scans. In fact I just got back from NY where I completed one of the most advanced ct heart scans in the world, the 640 slice.

      – Not sure about the “necessary” phytonutrients you’re speaking of. I do eat broccoli, salads, spinach, etc — but the most nutrient dense food I eat is liver, which I’m actually trying to eat more of as well.

      – Not all fats are the same nutrient profile, many are nutrient poor. But this is likewise true for greens as well.

      Interesting comments, Dwight. 🙂

  6. Eric Rodgers


    Interesting comments do you have any links to Atkins comments where he said he’d eat a lot more greens?



  7. Miguel

    Hello Dave,

    What you are doing is amazing! Thank you for your work! I am interested in your food log for the higher calorie days. I see your macros percentages but what foods did you intake to achieve such a higher saturated fat and protein? I would like to follow your experiment myself and I currently use Cronometer to track my foods. Thanks!

    1. Dave

      I ate a lot of cheese, eggs, heavy cream, AdaptMeal, burgers, Nathan’s skinless hotdogs, peanut butter and my low carb pizza to name a few.

      Try to fashion something you yourself would like to eat but still meets those macros. And try to do it with real food as much as possible. (i.e. don’t get the vast majority from, say, bulletproof coffee)

      1. Miguel

        Thanks! And, avoid coconut and MCT oil but what about Brain Octane Oil, coconut milk or cream? Would these effect lipid results?

        1. Miguel

          And is Extra Virgin Olive Oil ok?

  8. Jorge Estevao

    Monosaturate fats and fish oil are known to increase HDL and decrease LDL. Have you tried to increase these instate of satured fat on your diet and watch the results?

    1. Dave

      I did an 11-day experiment where I upped my MUFAs and reduced my SFAs early last year, but didn’t see a substantial change. That said, I’d like to do another that would be much more tightly controlled and this time I’d have the benefit of the CardioChek for more frequent testing as well.

  9. Gary

    just got my first panel back after starting Keto in July. went from 305 to 404, and all my other indicators, except tri’s and HDL are red flagged to the extreme. not quite sure where i am going to go next.

    fat is up/carbs down, fiber down from about 150/day to 20-25/day, sat fat up but not markedly.

    now it’s all a process of elimination but the testing cycle is a pain, I don’t have a lab I can pound blood into easily.

    1. Craig


      It sounds like you are comparing a pre-keto lab to a 2-months into keto lab. What all did you have tested? Could you post the TC/HDL/TG/LDL for those two tests? (We should have an article on recommendations for what labs to get, soon)

      My LDL-C and TC are also “flagged to the extreme”, but after doing a bunch of research and some additional testing, I’m not too worried. If TG dropped and HDL went up, those are very positive developments.


  10. Diane

    Has anyone who is not routinely low-carb tried your experiment? I’m on more of a high protein, low fat body-builder type diet and wonder if this would still work for me. I just want my doctor off my back. I refuse to take statins.

    1. Dave

      Sorry for the late reply, Diane — I just saw this…

      No — I don’t know that I’ve seen a lot of high protein, low fat and low carbers. But I am interested in your numbers if you’d like to post them. Of the few I’ve seen, there seems to be a slightly higher predominance of lower HDL relative to a typical LCHFer.

      1. Diane

        I have not tried your hack but my last test my numbers were:

        TRIG: 78
        Cholesterol: 312
        HDL: 77
        NON HDL CHOL. (LDL + VDL): 235
        LDLCALC: 219
        VLDL Cholesterol CAL: 16
        CHOLHDL: 4.1

        1. Dave

          The numbers look pretty standard for a hyper-responder on low carb — which is interesting given the protein-centric aspect of your diet.

          Thanks for the contribution, we’ll have Craig add to the data set.

  11. cibele

    Hi Dave, I just found out about you and your blog online and I’m already amazed.
    i did the keto diet for 3 months and at the end I have high cholesterol. I also have polycystic ovary syndrome and my doctor asked me to stop this high fat diet.
    Im on a regular diet, still low carb, but I definitely loved the keto diet…I was feeling amazing every single day, with a lot energy any time of the day.
    I started to google today about it since I really would like to go back to the keto diet at least during the week (5 days a week).
    what do you thing about this approach?
    maybe I should stay way from Saturated fat for a month and test my cholesterol again?
    you comments will be very important for me. thank you so much for sharing all this information.
    Thank you, cibele
    [DAVE NOTE: I removed your email as this site is crawled by spambots quite a bit!]

    1. Dave

      Hi Cibele,

      If you don’t mind, I’ve “referred” you to a fellow low carber who has PCOS and had tremendous success with keto. She’s fantastic and very insightful/researched on this ! 🙂

      1. Sofia

        I am interested in that too as I am Leto 8 months but pcos and hipo..thank you

        1. Dave

          Now that I have her permission, the one I’m referring to is Carolina Carier. You can reach her through her FB page here: https://www.facebook.com/CarolinaRevoWellness

  12. amy


    Please forgive me if the answer is here on the site somewhere–I’ve crawled around and can’t find it.

    For the cholesterol drop protocol, during the high calorie part, does the ratio of saturated to unsaturated fat seem to make a difference? Or is that something no one has looked at?


    – Amy

    1. Dave

      Generally not looked at too intently yet. I did do an 11 day experiment last year replacing SFA with M/PUFAs and didn’t have a high significant change, but I’ve heard of several (particularly ApoE4s) see a change.

      With regard to how this fits into the protocol, I’d say try to stick with whatever fats you’re mostly using anyway. If your diet is 10% saturated fats, try to keep it at 10% saturated fats at the higher quantities. If it’s 25%, shoot for 25% and so on.

      The idea is to be sure the composition is roughly the same to control for the variables. If you change the composition, that becomes one more thing that might have made a change in either direction that can’t be accounted for very easily.

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