Jun 09

Cholesterol Code Workbook 2: The Mysterious Lipoprotein(a)

On this episode of the Cholesterol Code Workbook, we discuss five papers about the most mysterious lipoprotein: Lipoprotein(a). We discuss its involvement in wound healing, its role as a carrier for oxidized phospholipids, and potential influences on risk for cardiovascular disease.

Take a seat, grab a snack, and join us as we venture into the puzzling curiosities of lipoprotein(a)!

Studies and Figures mentioned in this episode:

Note: All images used are for the purpose of discussion and entertainment, all credit is given to the original authors. Figures come from the studies they are represented under.

A Test in Context: Lipoprotein(a): Diagnosis, Prognosis, Controversies, and Emerging Therapies

doi: 10.1016/j.jacc.2016.11.042

New Insights Into the Role of Lipoprotein(a)-Associated Lipoprotein-Associated Phospholipase A2 in therosclerosis and Cardiovascular Disease

doi: 10.1161/01.ATV.0000280571.28102.d4

Oxidized Phospholipids, Lipoprotein(a), Lipoprotein-Associated Phospholipase A2 Activity, and 10-Year Cardiovascular Outcomes

doi: 10.1161/ATVBAHA.107.145805

Immunolocalization of Lipoprotein(a) in Wounded Tissues

doi: 10.1177/002215549704500408

Relationship between lipoprotein(a) concentrations and intima-media thickness a healthy population study

doi: 10.1177/1741826711423216

Other material mentioned:

Peter of Hyperlipid’s post on Bantu Lp(a) Levels


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24 Comments on "Cholesterol Code Workbook 2: The Mysterious Lipoprotein(a)"

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Dave, I really appreciate all your work on this subject. I just discovered you as I recently embarked on a Keto diet. I’ve seen a number of your YouTube presentations and read many of your blog entries (I have listened to your appearance on the Keto For Normies podcast at least three times now) and I think at this point I understand the basics of cholesterol and its effects on people who follow LC/HF diets – even though I wasn’t born with the brain of an engineer. That’s to your credit, the way you present this incredibly complex information in… Read more »
Haha I tried to keep up with this presentation, super interesting. Had a couple of questions I could be way off. If you had low HDL and higher triglycerides, do you think your body would produce more lp(a) to get ride of the oxidation caused my that and act as an hdl to remove the waste with a different pathway than the liver. (I’m probably way off in left field on this just a question ) Also if I just started lifting heavy weights and and my muscles are tearing and repairing bigger would that call for a bigger amount… Read more »
Jo Anne

Is there any known relationship between an elevated CRP level and an elevated Lp (a)?