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Jun 08

Cholesterol Code Workbook 1: The EAS Critical Response

The Cholesterol Code Workbook is a new regular video series Sioban Huggins and I are doing as we look at and discuss various studies and their findings. Be sure to subscribe to the channel to catch shows as they are released.

 

We jump into the very detailed paper that responds methodically to the EAS consensus study from last year.

Link to the study: https://www.karger.com/Article/FullTe… Link to the original EAS study it is addressing: https://www.ncbi.nlm.nih.gov/pubmed/2… The Top Ten list we reference is here: http://cholesterolcode.com/top-ten/

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AndrésJenniferMike+KramerSiobhan HugginsMike Recent comment authors

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Susan Jones
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Susan Jones

So much information, i will have to watch a few times to soak it all in! I need this information as i deal with a poor CAC score and “poor” lipid numbers. Thank you for your passion!

Mike
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Mike

This paper, as well at https://www.karger.com/Article/FullText/446704 , argue that olive oil inhibit vitamin K2 in stroke-prone hypertensive rats, hence should be avoided because of its potential to exacerbate CVD.

The PREDIMED study seemed to suggest a significant benefit for CVD with olive oil and a nonsignificant (p=0.11) benefit to all-cause mortality. https://www.nejm.org/doi/full/10.1056/NEJMoa1200303

That study had flaws and certainly the “Mediterranean diet” was an obfuscatory concept manipulated by bad old Ancel Keys.

But the evidence does seem muddled on olive oil. Any coherent thoughts?

Siobhan Huggins
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I don’t generally like any study involving anything-prone mice if trying to apply it to humans, especially if (as you noted) it conflicts with human data. Such as rat studies suggesting saturated fat is detrimental (in mice, on high-fat chow), but the epidemiological data (e.g. PURE) showing no increased risk and even possible benefit. Plus, in the mouse study it refers to potentially exacerbating CVD (in mice already prone to it), so if it did apply to humans, I doubt it’d apply to the entire population.
As far as olive oil goes, I’ve never seen any evidence to show it’s particularly beneficial in humans, nor particularly detrimental. In my opinion it’s more about what you’re not eating (seed oils? high amounts of sugar? white bread? ultra processed grains?) than eating of some particular substance. E.g. olive oil could have shown benefit in that trial because they started using it instead of something else, like grapeseed oil, or canola oil, or margarine (not sure how common those are in Spain, but you get my point)
I’d agree the hype over olive oil is probably largely due to Keys, and possibly encouraged by the olive oil industry (I believe I’ve seen some studies floating around that have been sponsored by them), but I don’t really see any particular reason to feel strongly about it one way or the other. It seems fairly neutral from what I’ve seen of it so far in studies based off of humans. In the “Use it if you like it” category.

Mike+Kramer
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Mike+Kramer

Thanks!

Andrés
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Other than some corn oil, it is mostly sunflower oil around here in Spain, some of it high oleic type. For me it’s been some years avoiding those and using olive oil and butter.

Jennifer
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Jennifer

This podcast was very interesting and informative especially asI have FH.
I don’t want to go into my history since I’ve already posted it on the pinned
Page.
Anyway years ago before my MI I was admitted to hospital for what turned
out to be a disasterous botched elective angioplasty. It was stopped abruptly
Because of 2 arterial disections ( which I was told was my fault).
I spent 2 weeks in hospital with a bypass looming over my head and heart.
.

I healed without any further treatment, I’m sure that whole episode didn’t
Help my heart health . Sent home with a goody bag of meds and got on with life.
After my heart attack I was researching alternative heart treatments and the truth
About cholesterol.This led me to longstanding research by Uffe Ravnskov and his
Reasoning sparked my interest around FH .
He was the only voice at that time ( that I knew of) suggesting a link to hpercoagulation,fibrinogen,VII disorders with FH people with CHD not quite sure
How many.
This prompted me to look up my old paperwork,and on 2 of my results that I had
At that time had asterisks on the coagulation ,prothrombin time VII ,nobody said anything but I remember at certain times in hospital over the years nurses taking blood remarked my blood was sludgy ,it became a bit of a joke.

6 months after MI ditched meds and started Vitamin K2 in quite large doses
5-15 mg along with A,D,E, and healthier lifestyle (sort of).

I’m very aware most FH causes no problems for most people and they live along and possibly healthier life ,but for a certain few is problematic .
Your podcast also found this link and this obviously needs more research.

Maybe if doctors tested F H subjects for coagulation disorders
This could prevent possible CHD down the line.
Look forward to your next podcast eagerly

Dave and siobhan you are both awesome.