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Aug 08

Cholesterol Code – Part V : More Fat, Less Cholesterol… to The Second Power

For the short version with pictures, see below. For the long version, read on after…

image

The Plan

A couple months ago I started talking to my sister about taking my data to the next level. But to do so, I’d need someone else’s help — to which she immediately volunteered. (Side note: my sister is uberawesome!)

In fact, my sister was perfect for what I wanted to test specifically. While her cholesterol numbers went up after going low carb last year, they didn’t rise nearly as much as mine. In fact, both her LDL-C and LDL-P were generally half of mine. Thus, we would have different starting points on our cholesterol when we ate, which is the goal.

Light Diet Day

Light Diet Day

I then started planning all our meals to be similar to my prior March week-long solo test. There would be the same day-by-day blood tests during one week. Only this time we’d add one test for the Friday before the week, and the trailing Monday that followed it, seven blood draws in all, each was an the advanced cholesterol test, NMR (Nuclear Magnetic Resonance).

Once started, we had to eat the same food at exactly the same time, no exceptions. Both of us had to take pictures of everything we ate, along with weighing them when possible. Half of the time she was in her state, then flew to me in my state where I’d then on prep, weigh, and cook our duel meals personally.

Generally, I tried to keep our food mostly home-prepared and stay away from processed or fast food. But both before the meal plan and following we ate out a little more. Also, my sister likes Zipfizzes, so we agreed to have one a day through the planned days as well.

Heavy Diet Day

Heavy Diet Day

Overall, the plan worked beautifully! My sister stayed religious to the diet and timing and we didn’t have any sudden surprises that thew us off the rails. I have a few fun stories that I’ll save for in person talks later.

The Comparative Data

Beyond the Total Cholesterol hook above, it’s worth looking closely at the other markers as well.

Our LDL-C was an impressive 88.9% correlative with each other! Did I put only one exclamation mark there? I meant three — 88.9% correlative!!!

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And here’s a relative comparison to really see the match up:

image

This was especially relevant to me given my general theory encompasses energy trafficking as being the primary driver of these LDL cholesterol payloads. If I’m losing you here a little, don’t worry, I’ll cover this in a future post.

Like my own data before this, HDL doesn’t often move too much, but typically tracks with three day dietary fat in a positive correlation. More fat, more HDL. Between the two of us, we correlated a solid 71%.

ID_HDL-C

This next piece of data is extremely relevant to me (which I’ll get into in the theory post). It also tends to have a high standard deviation relative to the other markers from my past tests. However — in this case it was remarkably close in comparison to each other’s at a 77%. Incredible!

ID_TRIGS

So here is where things get interesting. On both LDL-P and Small LDL-P, Darla and I track very closely with the exception of the very last data point (7/18). In fact, the metric is so off course as to be suspicious to me. Up to that test, we had been eating everything identically as with the others, so what happened?

I’m loathe to suggest a lab error, especially since the non-P metrics appear to line up correctly. But unfortunately, there’s no easy way to find out as I have no direct contact with the lab (as it should be). For now, I’ll list both the complete results and what the correlation is without it and you can judge for yourself.

ID_LDL-P

ID_smLDL-P

It’s hard to quantify in words how happy I am that we captured this data and confirmed the previous patterns I’ve observed to this point. Our next steps will a new N, Nicole Recine, a Ketogenic Practitioner who has graciously accepted being our #3. We’re currently in the planning phase and hope to set up the next capture in the coming weeks.

I couldn’t end this article without given a very sizable thanks to my sister, Darla, and her contribution to this science.

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53 Comments on "Cholesterol Code – Part V : More Fat, Less Cholesterol… to The Second Power"

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Bill Robinson
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Might 7/18 be hormonal?
Great work (three exclamation marks here)

Wenchypoo
Guest

I just got through listening to your podcast with Jimmy Moore, and wrote to say I had my own inverse episode with fat and cholesterol. Only doing NMRs yearly (with the physical),, I noticed that over the last 3 years (starting with 2016 and going backward), my LDL-C, LDL-P, VLDL, and trigs all went down when I started using a combination of fats (MCT, butter, coconut oil, lard, and avocado oil) made into fat bombs for cooking and blended into my salad oil. HDL rose from 70 to 99.

When I quit using this mix of fats, my NMR went to hell in a handbasket–my doctor (who THINKS I’m taking Crestor) wanted me to double the dosage. Instead of taking a statin, I just went back to my mix of fats. She wants to see me again in September for a cholesterol check, so it should be good (in her eyes).

My recommendation: eat ALL the fat–blend your sources to make fat bombs for cooking, and/or using the blend in your homemade salad dressing. Blend your chain lengths, and blend your UFAs and SFAs, keeping to the heat-stable ones for the cooking, and going nuts in the salad dressing (such as red palm oil).

Speaking of red palm oil, I recently read that it is supposed to lower LDL–I’m going to try an N=1 on this when my ordered bottle comes in Saturday. This oil will be used as a capsule, as my “cooking” fat bombs have already been made, and the salad dressing dressing already made (a full quart). If my September results show improvement, then I will add the red palm oil to the salad dressing fat lineup.

I WILL NOT STOP EATING FAT JUST BECAUSE MY DOCTOR FREAKS OUT ABOUT AN OUT-DATED AND WRONG INDICATOR!!!

Tim H
Guest

My experience has been of my cholesterol increasing as the percentage of fat in my diet increased but over 3 years, not a few days. My recent total cholesterol is 323, LDL 238 and HDL 89 following a diet of around 85% fat calories, 2 or 3% carbs. The high cholesterol has not worried me unduly given research such as Ravnskov U, Diamond DM, Hama R, et al. Lack of an association or an
inverse association between low-density-lipoprotein cholesterol and mortality in the elderly: a systematic review. BMJ Open 2016;6:e010401. doi:10.1136/bmjopen-2015-010401.

What has made me curious, however, is my GGT (gamma glutamyl transferase) numbers. Eating 70% fat (coconut oil, butter, palm oil) it was 13 U/I in 2013. Eating 85% fat (lard, coconut oil, butter) it has become 44 U/I in 2016. Can anyone shed light on this?

Rising GGT is normally associated with liver damage from alcohol (I manage a glass or two of wine in an entire month) or carbohydrate but I’m eating 2% carbs! Inflammation? Nope, my hsCRP is 0.872 mg/L! Both 2013 and 2016 GGT numbers are within reference range but at opposite ends. Why? Any ideas are welcome.

Ela
Guest

Hi Dave!

Thank you so much for doing all this work and laying it out like this. I listened to your conversation with Jimmy Moore, and I’m struck by how much sense your picture makes (and how it vitiates many mainstream medical assumptions).

I wanted to share some information that I think underscores the truth of your inverse correlation. I have a background history of extreme anorexia, probably developed to control my bipolar disorder, so I’m much happier now on a ketogenic diet (on the theory, which is borne out for me, that bipolar is a seizure disorder that responds to starvation, or keto).
It turns out (perhaps you knew this) that people with a history of starvation often have high cholesterol. The last time I had my cholesterol checked before starting in a keto direction, my numbers were scary high. Over 400 total, and HDL and trig higher than I’d have liked but not terrible. At the time, I wasn’t eating much period, and certainly not much fat.

Next time I had it taken, I was figuring out my ketogenic plan, was eating a lot of fat (especially coconut oil), more food in general, and my total cholesterol had dropped by 150 points; trig and HDL were fine.

Obviously this is a very incomplete encapsulation compared to the work you’re doing, but it seems to correlate well with what you’re saying about the inverse relationship.

Thanks again!
Ela

Nick
Guest

Awesome stuff! But surely this can’t be “new science”. can it? You mention going to Vail, so did you talk to any doctors/researchers that had seen this type of data?

Also, I noticed someone pointed you to Ken Sikaris’ excellent video (actually he’s done two that talk about hyper-responders) and since you went to Vail you no doubt saw Dr. Sarah Hallberg’s presentation on this (for those who haven’t seen it https://www.youtube.com/watch?v=w8jUmCe3zDs&list=PLrVWtWmYRR2BYjk-oQTlAtGCjnly3J7LB&index=5).

Are there any other videos on this you’d recommend?

Cheers,
Nick.

Bosse
Guest

Is it possible to get day-by-day data on dietary fat for the three day averages.

Fyi it’s not really correct to use averages for this kind of data. Especially without presenting deviation.

Also what’s going on at 7/15?

Eric
Guest

Look at doctor pandas work on time restricted feeding. The Salk institute has a free app to track time a d photo food intake. Eric

Dr. I
Guest

I am a 47 yr. old Family Physician, following initially a low carb, high protein, and low fat diet, now following a low carb, mod protein, high fat diet. I have lost 25 pounds to bring my body fat to 8 – 9 % and am as fit as ever. I have seen my Chol, HDL, HDL-P, LDL, LDL-P and LDL Size to increase significantly while my TG, TG/HDL ratio, small LDL-P to decrease significantly. I have read all of Peter Attia’s info and Ivor’s posts and video’s. Currently my HDL, TG, TG/HDL ratio, HDL-P, small LDL-P, LDL Size, and LP IR are as good as they have ever had measured but my LDL is exceedingly high at 292 and the Chol 385! HDL 80, TG 60.

I have read Taubs, Teicholz, Cholesterol Clarity, and Dr. Fung, and Dr. Gerber’s info. At this point my LDL makes my doctor, who is one of my partners, lose sleep but I am unconvinced the meaning of this outweighs my incredible HDL, TG, and TG/HDL ratio. Given the very high number needed to treat for statins to prevent one nonfatal MI for primary prevention and their side effects, I’m so far not treating the LDL.

In high responders such as us, is there any good data on the association of isolated elevated LDL-p with development of CAD? The mixture of indicators is confusing. Surely an HDL of 80 and a TG/HDL ratio of 0.75 can’t be incredibly good on the one hand while also having a really bad LDL-P. Which is more predictive? Does anyone even know?

Thanks for your very interesting observations and contributions to the discussion.

Nancy
Guest

So I went high fat and my LDL cholesterol shot through the roof, similar to your experience. I’ve read all your posts and listened to your interview with Jimmy Moore. It’s interesting data but I’m not sure how to apply this for my situation. My questions:

1) How dangerous is very high LDL?
2) Do we need to treat this with diet and statins?
3) If not dangerous, can you point me to further reading?

For now, I’ve cut back on fat, especially saturated fat, have added a statin and have started using olive oil as my oil of choice. Thanks in advance.

Nancy

Bill Robinson
Guest

A woman taking a statin?

Why?

IanA
Guest

Really appreciate the work you are doing and yes, I have readings like yours (when converted into Aussie units). So many unanswered questions in this area.

Tim F
Guest

Hi Dave.

Thanks very much for your efforts, they are incredible and really appreciated.

I am very much looking forward to your lipoprotein system theory.

In particular I will be looking for the following question answered:

If dietary fat is inversely related to LDL-C/LDL-P cholesterol on a relatively short term basis is there anything that would explain the very large rise in cholesterol on a long term basis for us LCHF hyperresponders, which is a sizeable group. IE if fat is supplying 65-75% of energy needs why does the body need such higher cholesterol and why in only some people.

I am thinking since chylomicrons are relatively short lived maybe the extra cholesterol is needed for trafficking lipids around the body and the cholesterol is mainly along for the ride (ie more efficiency means more activity).

Alternatively when insulin levels drop and fat can be manipulated more efficiently maybe the higher cholesterol numbers reflect cholesterol coming out of the body, not being ingested with diet or produced endogenously. This would seem to be supported by evidence that cholesterol numbers do stabilize over time.

Whatever, really looking forward to your theory.

Congratulations again on a job well done.

Richard B Arnesen
Guest

Hi Dave,

So glad I stumbled across this site. So much information! Also thanks for the link to the APOE4 forum (I am 3/4). Still not sure what the answer is but it is great to be part of the discussion. I’ve been LCHF for several years and keto off and on but in January of this year decided to get into keto again. I also finally convinced my doctor to give me the NMR test in March. Not great news as you would expect for a 3/4 (which i found about in February of this year). LDL-P was 1916, LDL-C was 140, HDL was 48, Trig 81, TC 204, Small LDL was 919. These all freaked me out a bit but now i have a better understanding. I’ve cut down on sat fat, a bit, and dairy, and I also started regularly IFing (basically not eating except for coffee with MCT and sometimes grassfed butter until 2pm or so). I just got retested Thursday and will have the results next week. Anyway, i am glad to hear you are going to do some experimenting with fasting and blood work. I will be very interested to see those results. Also, i am wondering if you have thought about doing some experiments with different types of fat? Seems like most people are saying that APOE4 types should replace most sat fat with MUFA.

Thanks!

Richard B Arnesen
Guest

Thanks Dave!

I will post my new numbers next week when get them. I too like my sat fat, and substantially all of it comes from pastured/grass fed sources. I just get a little freaked out being a 3/4 when i hear several sources (Steve Gundry and others) talk about eliminating most sat fat for 3/4 and 4/4s. I recently replaced bacon with sardines and salmon with my afternoon “breakfast”.

Regarding my numbers the thing i am most concerned about is the small LDL. Of course your experiments call in to question the relative importance of all the lipid markers. I mean, if they are that variable and “agile” what good is it to get a once a year test etc. I cant help but wonder what Peter Attia and others in this space would say about your experiments.

I guess after reading all that i have read (and I do not have a science or engineering background) my hope is that the answer is keep BG, Insulin, and inflammation markers low and don’t worry about the rest. It would be nice to have an answer on whether or not to be in ketosis. I get that it is likely my lipid numbers may improve if i went to say, 100-150 grams of good quality carbs, but is that necessarily a good thing given that the carbs could affect by BG, Insulin and inflammation..

Richard B Arnesen
Guest

New numbers from 10/27/16
TC: 267
LDL-P: 2069
Small LDL-p: 1028
HDL C: 56
TRIG: 101
hsCRP: 0.3
Ha1C: 5%

So my HDL went up from 48 to 56 which is great, and my hsCRP is low. All the other numbers stayed the same or went up marginally. I should also point out that my BG which i check frequently, is almost always between 75-90 and my ketones are usually 1.0 – 3.5. Generally i feel good, I workout often and have bodyfat of around 10%. I think my step would be a CAC scan. My doctor of course wants to put me on a statin. For most of my life (i’m 51), my Total C has been below 200 and LDL-C has been low but those early tests were not NMR so i don’t have anything to compare to.

Richard B Arnesen
Guest

Thanks again Dave! It is very frustrating not knowing what direction to go. I eat what i think is a very health keto diet. No sugars or grains of course, lots of leafy green veggies, all or substantially all animal fats and proteins are pasture raised etc. I have recently cut back on dairy (I am in Wisconsin so not easy to do) and added more olive oil but my numbers, with the exception of the HDL and Trigs look like i am on a SAD. I have a hard time believing that the answer is to go back to eating carbs when by BG is low and stable and my hsCRP is low at .3. I may try to get out of keto for 3 or 4 weeks by eating 100 grams or so carbs (sweet potatoes or similar) and cutting out the daily dose of bulletproof coffee and then test again.

Yes I am familiar with BJJ. Haven’t been on his site for awhile so i will check it out. If you are ever looking for another n=1 let me know if meet up for it.

Rich

Leo Tat
Guest

Hi Dave,

Back a few years in 2014 when I started a low carb high fat diet, I tested my blood after 4 months.

TG and HDL ratio is one of the best indicators of cardiovascular disease risk.

Heres mine:

TG/HDL = 70.88/69.66 = 1.05

My wife started at the same time as me, took the test too and got

TG/HDL = 70.74/69.66 = 1.15

These are pretty much perfect figures.

Dr. Trent Hippard
Guest

Hi Dave,

I am a new to your research and work but fell upon it as I received my lipid panel and the numbers shocked me as I’ve never had elevated cholesterol levels (being fit and althetic for over 20 years). I’m also as I should mention a Doctor of Chiropractic that runs a pediatric and family wellness practice (lifestyle and environmental factors are huge focus in helping my members). I’m turning 33 in September and have been doing ketogenic diet for last 9 months in which it has been very helpful in my recovery process from workouts, work and decreased the inflammatory issues I’ve noticed popped up over the last few years from training hard and helping lots of people in our office (physically adjusting the spine).

My TC came back 301, LDL 233, HDL/ratio was 5.2 and I had CRP done but have not seen the result sheet yet (as all of this has been reported through a phone message from the lab assistant).

Couple questions:

1) should I order a NMR?

2) should I decrease SF intake and increase MUSF? Currently I eat limited dairy, but do eat bacon (1lb-1.5lbs) a week mixed in with leafy greens (non starchy carbs) with my meals (I eat 2x a day). IF is part of my routine (18 hrs, 8 HR window for eating). I don’t drink coffee or bulletproof coffee, have switched meats to more lean ones, increased my protein intake to 1g per lean body mass (144 g a day), keeping my net carbs to 25g and under 50g a day. I keep my electrolytes in check, workout 3-4 days a week with HIIT and weight training. Tracking my macros for the whole 9 months+. I’ve practiced cyclical ketogenic (breaking once week or every 2 weeks a higher carb day).

3) am I missing something? BG levels avg 80-95 while fasted and ketones stay in a range of .2- 1.0

4) I will not go on medications as I believe I can tweak this through nutrition. Is ketogenic diet right for me? Or is it not ideal for hyper responders? I’ve received great benefits from keto just lost for words why my levels are like this.

5) any recommendations for listing of reading resources to help?

Theank you!

– Trent Hippard, D.C.

Esther Loopstra
Guest

Hi Dave,
Thank you so much for the work that you are doing. I just donated! I’ve been following you for a while but just watched your video The Dynamic Influence of a High Fat Diet on Cholesterol Variability’ and finally sort of put it all together.
I have hypertryglicedemia (my mother and brother both nearly died of pancreatitis at age 40 and my mother died of pancreatic cancer) as well as hyperlipidemia.

I’m currently age 41 and about 5 years ago, my trigs were about 750 – I happened to try an elimination diet to get rid of migraines and took a blood test during. My trigs were NORMAL! The doctors said that this would never happen because of my inherited condition.

So, I began to realize (even though I wasn’t doing lchf) that there was something to this low carb idea. I was only cutting out any processed foods – especially bread, pasta, crackers, cookies, etc. and I prefer to eat vegetarian so it wasn’t super low carb. However, my total ldl c and ldl p were still super high.

I’ve been systematically (although I haven’t been anywhere as good as you about recording what i eat) trying various things and taking the blood tests over the past 5 years.

The lowest my lowest numbers were trigs – 107, small ldl-p 481, ldl-p 2184, hdl-c 53.
Normally, my trigs are around 130-150, small ldl-p is anywhere from 1,500->2300 and ldl-p over 2,300.

I tried the keto diet for 3 months a couple years ago and I felt absolutely HORRIBLE. I couldn’t sleep, felt tired, anxious, moody. It was awful and my scores where not too different.
Trigs 106, small ldl-p 1524, ldl-p 3259, hdl-c 56
And to top it off, I really prefer to eat vegetarian/ vegan because I hate meat so it was really difficult.

I’m curious if you’ve had any people respond to you who have hypertryglicedemia – I’m wondering how it affects the numbers. I really want to try to do your experiment with my next blood test. luckily my MD is totally into all of this stuff and I have sent her your website multiple times! Both my MD and ND are worried about the future of my health although most of my other markers are pretty good.

Any advice for me or thoughts before I do this? Did you ever hear back from the gentleman at the conference who does a vegan hflc diet?

Also interested if you’ve gathered any other data on the introducing carbs experiment and what I could try in regards to that.

I would love to share my results with you in the future (I am non – postmenopausal female ) haha
Sorry for this long post!
Esther

Katrina
Guest

I am a 44 year old female that has been on a low carb diet for two years. I have lost 74 pounds but have had an increase in my cholesterol numbers. This is very disappointing to me because if I do not get it lowered, my insurance premium will go up and if I refuse meds, I will lose my insurance all together.
My most recent results are as follows:
Total cholesterol – 238
HDL – 53
TRI – 90
LDL 167
% HDL 22

I did try the three day experiment and went this morning for results. I haven’t gotten them yet but I have to say that I am nervous.

I would like to share my numbers with you and maybe you can tell me if it looks like I did the experiment correctly…

Day 1
2830 Calories
31 total carbs
243 fat

Day 2
2780 Calories
22 total carbs
233 fat

Day 3
2156 Calories
28 total carbs
166 fat

Day 4 – Half day of eating and started my 16 hour fast to prepare for labs…
2330 Calories
43 total carbs
212 fat

Does this look like I had enough fat and calories to lower the cholesterol? I am desperate for positive results.

Katrina
Guest

Received my lab results and I have to say I am very pleased. I was very doubtful and skeptical because of the struggle I have had to lower my numbers. The following results are after doing the three day experiment.

Total cholesterol – 205; it was 238
HDL – 66; it was 53
TRI – 71; it was 90
LDL – 125; it was ; 167
% HDL Cholesterol 32

I could only eat a little over 2000 calories a day, mostly from fat. I want to try the experiment again and increase the calories to 3000 if possible.
Any suggestions are welcome as I continue the low carb journey. I still have about 15 pounds that I want to lose and then just maintain. I started at 216 and am currently at 143.
If anyone has suggestions on losing fairly quick, please share.

Craig
Admin

Katrina,

That’s awesome!

Unless you have a particular LDL or TC target (that your doc or insurance wants), it’s probably not worth the trouble to repeat the Feldman drop experiment again. It’s tough to overeat that much!

Random advice for a new low carber:
Eliminate the seed oils and learn to look out for contamination when eating out. Slow and steady on the weight loss. If you get stuck at a plateau, throw in some intermittent or extended fasting.

Craig

Katrina
Guest

Thank you so much for the advice. My insurance company wants my total cholesterol under 200. So, tell me, does it really not harm your body to have so much fat? Even on a regular daily basis of eating low carb, you have a higher fat intake. My husband is really getting on me about having so much fat. He is worried about a heart attack. What advice does anyone have concerning this issue? Over all, my main goal is that I want to be healthy.

Anderson
Guest

Unless I wasn’t paying attention, I seem to remember some studies suggesting that higher cholesterol was related to lower instances of CAD. Yet, we’re seeing high fat diets decreasing cholesterol…

Tiago
Guest

Dave: First I would like to Thank You for sharing all this information and being a so competent scientist. It is really incredible how all this info makes sense and at the same time, goes against everything that we have heard. Well, I guess I am a Hyper Responder as well. Took my blood test in February and my total cholesterol was around 190/200. Started a low carb diet and two months later my total cholesterol was 310! I found your blog and started digging into the subject. I have a question for you. Correct me if I’m wrong but you said that you don’t know if a high LDL-C in a LCHF diet is dangerous or not but there reasons to believe that a high LDL-C could be irrelevant. So, what are your thoughts about the ApoB/ApoA1 relation? Don’t you think that having a LDL-C could lead a bad ApoB/ApoA1 relation?

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