Jan 20

START HERE (Pinned)

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  • If you know little to nothing about cholesterol->
    • And you want to learn the basics->
      • You can check out my Simple Guide to Cholesterol series. It’s full of illustrations and is written for laypeople. Enjoy!
      • Likewise, I have this video that goes over the basic markers for cholesterol while on a low carb diet. (Pictured to the right)
    • You can enter your cholesterol numbers into our popular Report tool to check them against many risk calculations at the same time.
  • If you’re wanting to know about my research->
    • You want an overview->
    • You want the most recent breakthroughs->
      • 1/2/2018: In this latest video, I demonstrate massive changes to my LDL Cholesterol over 5 stages in a matter of days. LDL 207 to 103 mg/dL in seven days with high carb, up again to 146 on mixed, down again to 113 on high fat. (Pictured to the right)
  • If you have seen your cholesterol rise considerably on a low-carb high-fat diet (like myself):
    • You may want to first visit the FAQ.
    • I would strongly encourage you to read through this blog and my own journey revealing the Inversion Pattern. Key moments were the Identical Diet experiment and the Extreme Cholesterol Drop experiment that I wrapped around the first presentation of my data for the Ketogains Seminar.

Aug 20

Cholesterol Research Survey

Click HERE to take the survey

We’re collecting:

  1. What diet you’re on and for how long
  2. What your most recent cholesterol numbers were on that diet
  3. What your last cholesterol numbers were before you started the diet
  4. Your name and email (this is for internal records of the CholesterolCode team only and will not be distributed in any way without consent — no spam!)

 

Aug 13

#LCCholesterolChallenge Six Month Update

Today is the six monthaversary of my #LCCholesterolChallenge. Half a year ago I posted the following graphic:

And to date, no one has provided a non-drug, non-gene study showing people with high HDL + low triglycerides + high LDL exhibiting high rates of cardiovascular disease.

So today I’m going to step it up… big time!

The Un-Terms

I wanted to hold a contest for people to meet this challenge and set specific targets. After chatting with friend of mine who is a lawyer, he pointed out that there’s a lot of legalese once you hold a “contest” (or even use the word) that can get a be very complex to comply with. So he suggests I announce this as a “fun challenge” that “may” motivate me to reward participants.

So let me state it like this: I’m very, very interested in studies that meet the criteria I outline below. I have a budget of $1,000 that I’ll be drawing on to give (via PayPal) as I see fit for people who submit links to such studies in the comments section of this blog post. Obviously, first-to-post on each specific study matters a lot to me. I’m thinking around $300 for a study that hits that criteria sounds pretty exciting, but I’m not officially saying one way or the other.

You know what also sounds neat? Studies that show the opposite (like the ones mentioned below). So if people find studies that meet the below criteria with the exception of having LOW CVD or CHD, I’m thinking of possibly something around $100 would be exciting.

Once I’m out of that budget, I probably won’t be giving away any more.

But for legal purposes, everything I say above is all arbitrarily decided and in no way constitutes an explicit promise or commitment. Okay, lawyers?

The Criteria I’m Looking For

To set up specific targets, I’m going to use one of the studies that showcases the opposite result (high LDL, yet with low heart disease) — the Framingham Offspring study.

And as per the challenge, I want to get a sample of people who aren’t selected in or out for genetics or drugs that impact their lipid system.

So here’s the criteria, pure and simple — all of which must be met for a given group in the submitted study:

  1. HDL Cholesterol of 50 mg/dL or above (≥ 1.29 mmol/L)
  2. Triglycerides of 100 mg/dL or below (≤ 1.13 mmol/L)
  3. LDL Cholesterol of 130 mg/dL or above (≥ 3.36 mmol/L)
  4. Either high Coronary Heart Disease (CHD) or high Cardiovascular Disease (CVD) (see the section below)
  5. By “normal” and “non-treated“, I mean:
    • No stratifying by specific genetics
    • No stratifying by drugs (no drug studies)
    • No stratifying by a particular illness in advance of the study. (duh!)
    • In other words, just a generally broad group of people like Framingham Offspring or the Jeppesen study
  6. And here’s some fine print that should be obvious, but just in case…
    • The study needs to be published in a reputable journal
    • It has to be dated before this article was posted, of course
    • The study needs to have at least 400 participants that are stratified by this criteria. (The two studies above have over 500)
    • I’d prefer no unusual “modeling” or “adjustments” to alter the data too far from it’s original set. This one goes by the honor system — if you have such a study and it is clearly warranted, I can give it a pass.

What is Considered High Rates of CVD or CHD?

The most recent statistics I was able to find on Cardiovascular Disease (CVD) comes from National Center for Health Statistics and National Heart, Lung, and Blood Institute. Their data is reflected in this article from Harvard Health Publishing, Heart Disease: A Guide to Preventing and Treating Coronary Artery Disease.

For Coronary Heart Disease (CHD), we can go with the most recent data I was able to find from the American Heart Association.

In other words, I’m very interested in studies that meet the criteria from the above section and exceed the rates of either CVD or CHD of this section.

Thus, we’re not even talking “high” rates of these diseases — just “above average”.

Final Thoughts

Clearly I’m extremely interested in gathering more evidence — for or against — this challenge.

I could write about 10 pages of thoughts on why I consider it beyond astonishing that this “triad” hasn’t gotten more focus, but I’ll save that for another post.

Aug 10

Lipid Related Study Roundup – Part 1

 

Last week, during a meeting, Dave brought up the idea for me to go on a formal hunt for any studies that fit the triad outlined in his Low Carb Cholesterol Challenge. I tend to spend a fair bit more time digging through studies than he does, and a fresh set of eyes can help with any task. Plus, by digging through hundreds of papers you never know what you’ll turn up. As a result of this expedition I found some papers that, although not what I was looking for, were certainly fascinating and worth sharing. Although this isn’t all of the papers I came across, it is a list of the most interesting ones, in my eyes. I’ll likely do these roundups occasionally, especially as I come across particularly fun or pertinent studies, so I hope you enjoy.

Read the rest of this entry »

Aug 03

Journey to San Diego

While I was originally going to San Diego for the Low Carb USA conference, I ended up adding a couple more stops to the adventure…

Interview on The Peter Attia Drive podcast

As mentioned earlier, I guested on Attia’s podcast. It was a pleasure to meet Peter and his staff and we got to chat briefly before and after the podcast.

The recording itself ran to three and a half hours (!) and no, I won’t be revealing much from it. But there will be an upcoming blog post here where I relay his position on risk and his suggested tests for hyper-responders.

I do think the podcast will get lots of chatter after it is released and I’ll certainly have some additional thoughts to add as well. All in all, I considered this a very positive experience and look forward to sharing it with everyone.

If you haven’t already, I highly recommend Peter’s podcast which you can subscribe to here:

The Peter Attia Drive

Two Documentary Interviews

I was also filmed for a couple interviews to some upcoming documentaries.

A fun fact to know and tell is that I actually went to film school almost twenty years ago. I wanted to feel out the possibility of writing and directing movies, and I was looking at going the independent film route. Ironically, I was doing far too well in writing code and building programs while watching these poor starving wouldbe filmmakers all around me which probably played a big part of why I headed further toward technology.

Naturally, I’ve been very aware of just how much things have changed since then, especially with large LED fill lights, surprisingly small 4k cameras, and of course, massive, super fast access SSD drives. The me of two decades ago is certainly very jealous!

One of the interviews I sat for is Vinnie Tortorich’s Fat Documentary. Here’s an excerpt from the campaign:

Vinnie Tortorich is a health and fitness expert who has spent almost 40 years showing people how to lose and keep off weight. His book, Fitness Confidential  and podcast of the same name have helped and inspired people to reach their goals. He’s been a personal trainer to people from all walks of life for thirty-seven years and wants Fat: A Documentary to help change lives.

The film will be directed by Peter Pardini, director and producer of the acclaimed documentary Now More Than Ever: The History of Chicago, which chronicled the storied history of classic rock group Chicago. It premiered to #1 ratings on CNN in January 2017 and was a #1 best seller on Amazon. It is currently on Netflix.

Needless to say, this is going to be a highly watched film in the low carb community.

Low Carb USA

Photo credit: Chris Bair of KetoChow

For my presentation, I covered a lot of the core concept with the Lipid Energy Model and will soon have new material that streamlines it more as well.

The biggest thunderclap came with my reveal on the CIMT data to really drive home the key point on regression on the keto diet at super high levels of LDL-C and LDL-P — along with its unfortunate reversal following my Standard American Diet (SAD) experiment to gain weight. While I certainly am banking on the CIMT returning to regression following my going back to keto, I can say I’m happy to have caught the data to share with everyone else.

 

So the next time someone says they’re going to “take a break from my diet for the holidays,” be sure to show them my data!

Great Friends and New Connections

 

 

 

 

Jul 23

Ketofest Cholesterol Presentation Blowout

Yesterday was an amazing experience!

It was the second Ketofest held by the 2 Ketodudes in New London, CT. And as with the first year, the last day was reserved for “Science Sunday”. On deck were many speakers including yours truly. But never mind my presentation, I want to tell you about three others that cumulatively made my year…

The Paradox of Insulin Resistance versus LDL Cholesterol – Dr. Nadir Ali

Nadir had an extremely fascinating discussion on LDL cholesterol, insulin resistance, longevity, and even the problems with how industry conducts the science on how we study heart disease.

He had a number of graphs, flow charts, and illustrations that brought through the message impressively. He even covered lesser known protective aspects of LDL such as disrupting quorum sensing used by bacteria.

Your Marvelous Mevalonate Machine vs the Statin Slayer – Nick Mailer

I don’t even know where to begin with this spectacular presentation. Nick took us on an animated journey though biochemistry like nothing I’d ever experienced before. He painstakingly animated nearly every slide so we could observe the processes he was describing in deep detail as though it were happening in front of our eyes.

While it was delightful to see his naming me as one of his inspirations for taking his presentation in this direction, I can assure you he certainly took this to the next level. If you like my use of animations for presentations, imagine this increase by an order of magnitude… and for the record, I’m being quite literal here!

LDL: Primed to Protect (Cholesterol’s role in defense and repair) – Siobhan Huggins

I saved Siobhan’s speech for last as I can’t even begin to describe impressive it was. She has been working tirelessly on it for quite a while, and the effort truly shows. She managed to strike the perfect balance between dense content and friendly, accessible illustration.

She discussed her personal journey into the research, the many roles of LDL, Lp(a), and the lipid system as a whole. Moreover, she elucidated the common misconception of inflammation and how it should be understood for the process of repair rather than the problem it’s addressing in the first place. And perhaps most important of all, she wraps it up with a discussion on the importance of not taking any marker in isolation and to see the system as a whole.

It’s worth pointing out this was Siobhan’s first presentation in front of a live audience and as many of us agreed, she knocked it out of the park. 😀

A Truly Good Day

As I remarked several times yesterday, I felt genuinely ecstatic for how powerful the messages came across from everyone above on the subject of lipids and cholesterol in particular. I’m not sure when all these videos will be available on YouTube, but we’ll certainly have a post up when they are — and I’d certainly give each of them my highest recommendation.

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